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• W4365150468 abstract "Introduction Immune thrombocytopenic purpura (ITP) is an acquired condition caused by autoantibodies against platelet antigens. Some studies report an increased risk for cardiovascular disease in patients with ITP. However, the effect of ITP on Acute heart failure (AHF) is poorly documented. Our study sought to estimate the impact of ITP on clinical outcomes of hospitalizations for acute heart failure using the national database. Methods We queried the National Inpatient Sample (NIS) database from 2016 to 2019. The NIS is the largest inpatient hospitalization database in the United States. The NIS was searched for hospitalization of adult patients with AHF as a principal diagnosis with and without ITP as a secondary diagnosis using ICD-10 codes. The primary outcome was inpatient mortality. The secondary results were Acute Kidney Injury (AKI), Cardiogenic shock (CS), length of hospital stay (LOS), and total hospital charge (THC). Multivariate logistic and linear regression analysis were used accordingly to adjust for confounders. Results About 1,100,639 patients were admitted for AHF; approximately 0.2% (2,224) had underlying ITP. Cohorts with ITP vs No ITP had a mean age of 74.2 years [CI 72.8 - 75.6] vs 70.9 years [CI 70.8 - 71.1]; male (52.8% vs 52.3%), female (47.2% vs 47.7%); white (75.2% vs 70.2%), black (13.9% vs 17.7%), and Hispanic (6.5% vs 7.2%). Compared to patients without ITP, patients admitted with coexisting ITP had similar inpatient mortality (5.0% vs 2.8%, AOR 1.47, 95% CI 0.91 - 2.36, P 0.116), AKI (31.7% vs 27.4% P 0.225) and CS (4.7% vs 2.9%, P 0.135) compared to those without ITP. However, patients with co-existing ITP had a statistically significant increase in LOS (7.4days vs 5.4days, 95% CI 1.13 - 1.30, P 0.0001) and THC ($77,106 vs $51,962 P 0.003) compared to those without ITP. Conclusion In conclusion, patients admitted primarily for acute heart failure with co-existing ITP had similar inpatient mortality, AKI, and cardiogenic shock. ITP group had an increase in mean LOS and THC. Hence, ITP may increase the economic burden on patients with AHF. Immune thrombocytopenic purpura (ITP) is an acquired condition caused by autoantibodies against platelet antigens. Some studies report an increased risk for cardiovascular disease in patients with ITP. However, the effect of ITP on Acute heart failure (AHF) is poorly documented. Our study sought to estimate the impact of ITP on clinical outcomes of hospitalizations for acute heart failure using the national database. We queried the National Inpatient Sample (NIS) database from 2016 to 2019. The NIS is the largest inpatient hospitalization database in the United States. The NIS was searched for hospitalization of adult patients with AHF as a principal diagnosis with and without ITP as a secondary diagnosis using ICD-10 codes. The primary outcome was inpatient mortality. The secondary results were Acute Kidney Injury (AKI), Cardiogenic shock (CS), length of hospital stay (LOS), and total hospital charge (THC). Multivariate logistic and linear regression analysis were used accordingly to adjust for confounders. About 1,100,639 patients were admitted for AHF; approximately 0.2% (2,224) had underlying ITP. Cohorts with ITP vs No ITP had a mean age of 74.2 years [CI 72.8 - 75.6] vs 70.9 years [CI 70.8 - 71.1]; male (52.8% vs 52.3%), female (47.2% vs 47.7%); white (75.2% vs 70.2%), black (13.9% vs 17.7%), and Hispanic (6.5% vs 7.2%). Compared to patients without ITP, patients admitted with coexisting ITP had similar inpatient mortality (5.0% vs 2.8%, AOR 1.47, 95% CI 0.91 - 2.36, P 0.116), AKI (31.7% vs 27.4% P 0.225) and CS (4.7% vs 2.9%, P 0.135) compared to those without ITP. However, patients with co-existing ITP had a statistically significant increase in LOS (7.4days vs 5.4days, 95% CI 1.13 - 1.30, P 0.0001) and THC ($77,106 vs $51,962 P 0.003) compared to those without ITP. In conclusion, patients admitted primarily for acute heart failure with co-existing ITP had similar inpatient mortality, AKI, and cardiogenic shock. ITP group had an increase in mean LOS and THC. Hence, ITP may increase the economic burden on patients with AHF." @default.
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• W4365150468 title "Immune Thrombocytopenic Purpura Is Not Associated With Increased Mortality In Patients Hospitalized With Acute Heart Failure: A Nationwide Analysis" @default.
• W4365150468 doi "https://doi.org/10.1016/j.cardfail.2022.10.322" @default.
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