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- W4365442743 abstract "Inflammatory bowel disease (IBD) is a complex disease, caused by aberrant immune responses to environmental stimuli where genetic, metabolomic, and environmental variables interact to cause mucosal inflammation. This review sheds light on the different drug and patient related factors that affect personalization of biologics in IBD treatment.We utilized the online research database PubMed to carry out literature search pertaining to therapies in IBD. We incorporated a combination of primary literature as well as review articles and meta-analyses in writing this clinical review. In this paper, we discuss the mechanisms of action for different biologics, the genotype and phenotype of patients, and pharmacokinetics/pharmacodynamics of drugs, as factors that influence response rates. We also touch upon the role of artificial intelligence in treatment personalization.The future of IBD therapeutics is one of precision medicine, based on the identification of aberrant signaling pathways unique to individual patients as well as exploring the exposome, diet, viruses, and epithelial cell dysfunction as part of disease pathogenesis. We need global cooperation for pragmatic study designs as well as equitable access to machine learning/artificial intelligence technology to reach the unfulfilled potential of IBD care." @default.
- W4365442743 created "2023-04-15" @default.
- W4365442743 creator A5015939734 @default.
- W4365442743 creator A5062491410 @default.
- W4365442743 date "2023-04-03" @default.
- W4365442743 modified "2023-10-16" @default.
- W4365442743 title "Personalizing therapy selection in inflammatory bowel disease" @default.
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- W4365442743 doi "https://doi.org/10.1080/1744666x.2023.2185605" @default.
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