Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365442918> ?p ?o ?g. }
- W4365442918 endingPage "6313" @default.
- W4365442918 startingPage "6301" @default.
- W4365442918 abstract "A total of 35 piperazine derivatives were designed and synthesized, and their activities against tomato spotted wilt virus (TSWV) were evaluated systematically. Compounds 34 and 35 with significant anti-TSWV activity were obtained. Their EC50 values were 62.4 and 59.9 μg/mL, prominently better than the control agents ningnanmycin (113.7 μg/mL) and ribavirin (591.1 μg/mL). To explore the mechanism of the interaction between these compounds and the virus, we demonstrated by agrobacterium-mediated, molecular docking, and microscale thermophoresis (MST) experimental methods that compounds 34 and 35 could inhibit the infection of TSWV by binding with the N protein to prevent the assembly of the virus core structure ribonucleoprotein (RNP), and it also meant that the arginine at 94 of the N protein was the key site of interaction between the compounds and the TSWV N target. Therefore, this study demonstrated the potential for forming antiviral agents from piperazine derivatives containing α-ketoamide moieties." @default.
- W4365442918 created "2023-04-15" @default.
- W4365442918 creator A5001418213 @default.
- W4365442918 creator A5010483495 @default.
- W4365442918 creator A5037275727 @default.
- W4365442918 creator A5058341414 @default.
- W4365442918 creator A5065245523 @default.
- W4365442918 date "2023-04-13" @default.
- W4365442918 modified "2023-10-16" @default.
- W4365442918 title "Piperazine Derivatives Containing the α-Ketoamide Moiety Discovered as Potential Anti-Tomato Spotted Wilt Virus Agents" @default.
- W4365442918 cites W1564316529 @default.
- W4365442918 cites W2012399976 @default.
- W4365442918 cites W2016527903 @default.
- W4365442918 cites W2020600827 @default.
- W4365442918 cites W2029367671 @default.
- W4365442918 cites W2047047793 @default.
- W4365442918 cites W2118911862 @default.
- W4365442918 cites W2137972304 @default.
- W4365442918 cites W2340777637 @default.
- W4365442918 cites W2604468217 @default.
- W4365442918 cites W2616972217 @default.
- W4365442918 cites W2741342282 @default.
- W4365442918 cites W2754951621 @default.
- W4365442918 cites W2900762344 @default.
- W4365442918 cites W2916943584 @default.
- W4365442918 cites W2938466621 @default.
- W4365442918 cites W2998410463 @default.
- W4365442918 cites W3005701116 @default.
- W4365442918 cites W3026522683 @default.
- W4365442918 cites W3034353805 @default.
- W4365442918 cites W3035607084 @default.
- W4365442918 cites W3134561418 @default.
- W4365442918 cites W3138132283 @default.
- W4365442918 cites W3163012586 @default.
- W4365442918 cites W3168443948 @default.
- W4365442918 cites W3171115841 @default.
- W4365442918 cites W3186970134 @default.
- W4365442918 cites W3200823827 @default.
- W4365442918 cites W3203060429 @default.
- W4365442918 cites W3207323720 @default.
- W4365442918 cites W3210570522 @default.
- W4365442918 cites W3217194495 @default.
- W4365442918 cites W4200583869 @default.
- W4365442918 cites W4206926688 @default.
- W4365442918 cites W4281753123 @default.
- W4365442918 cites W4282940711 @default.
- W4365442918 cites W4283264591 @default.
- W4365442918 doi "https://doi.org/10.1021/acs.jafc.3c01361" @default.
- W4365442918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37052574" @default.
- W4365442918 hasPublicationYear "2023" @default.
- W4365442918 type Work @default.
- W4365442918 citedByCount "0" @default.
- W4365442918 crossrefType "journal-article" @default.
- W4365442918 hasAuthorship W4365442918A5001418213 @default.
- W4365442918 hasAuthorship W4365442918A5010483495 @default.
- W4365442918 hasAuthorship W4365442918A5037275727 @default.
- W4365442918 hasAuthorship W4365442918A5058341414 @default.
- W4365442918 hasAuthorship W4365442918A5065245523 @default.
- W4365442918 hasConcept C159047783 @default.
- W4365442918 hasConcept C159110408 @default.
- W4365442918 hasConcept C178790620 @default.
- W4365442918 hasConcept C185592680 @default.
- W4365442918 hasConcept C2522874641 @default.
- W4365442918 hasConcept C25824698 @default.
- W4365442918 hasConcept C2776201271 @default.
- W4365442918 hasConcept C2776568683 @default.
- W4365442918 hasConcept C2779635636 @default.
- W4365442918 hasConcept C41685203 @default.
- W4365442918 hasConcept C55493867 @default.
- W4365442918 hasConcept C71240020 @default.
- W4365442918 hasConcept C71924100 @default.
- W4365442918 hasConcept C86803240 @default.
- W4365442918 hasConceptScore W4365442918C159047783 @default.
- W4365442918 hasConceptScore W4365442918C159110408 @default.
- W4365442918 hasConceptScore W4365442918C178790620 @default.
- W4365442918 hasConceptScore W4365442918C185592680 @default.
- W4365442918 hasConceptScore W4365442918C2522874641 @default.
- W4365442918 hasConceptScore W4365442918C25824698 @default.
- W4365442918 hasConceptScore W4365442918C2776201271 @default.
- W4365442918 hasConceptScore W4365442918C2776568683 @default.
- W4365442918 hasConceptScore W4365442918C2779635636 @default.
- W4365442918 hasConceptScore W4365442918C41685203 @default.
- W4365442918 hasConceptScore W4365442918C55493867 @default.
- W4365442918 hasConceptScore W4365442918C71240020 @default.
- W4365442918 hasConceptScore W4365442918C71924100 @default.
- W4365442918 hasConceptScore W4365442918C86803240 @default.
- W4365442918 hasFunder F4320321540 @default.
- W4365442918 hasFunder F4320327912 @default.
- W4365442918 hasIssue "16" @default.
- W4365442918 hasLocation W43654429181 @default.
- W4365442918 hasLocation W43654429182 @default.
- W4365442918 hasOpenAccess W4365442918 @default.
- W4365442918 hasPrimaryLocation W43654429181 @default.
- W4365442918 hasRelatedWork W1969559874 @default.
- W4365442918 hasRelatedWork W1995337127 @default.
- W4365442918 hasRelatedWork W2007172166 @default.
- W4365442918 hasRelatedWork W2065605110 @default.
- W4365442918 hasRelatedWork W2072344609 @default.