FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365448858> ?p ?o ?g. }

• W4365448858 abstract "Background: Sugammadex is known to reverse neuromuscular blockade induced by non-depolarizing agents. In children, the recommended dose for reversal of moderate neuromuscular blockade is 2 mg/kg. We investigated the pharmacokinetics and pharmacodynamics of sugammadex in Korean children. Methods: Children (2–17 years of age) undergoing brain or spine surgery were enrolled and randomly assigned to control (neostigmine) and 2, 4, or 8 mg/kg sugammadex groups. Following induction of anesthesia and monitoring of the response to train-of-four stimulation, 1 mg/kg rocuronium was intravenously administered. Upon reappearance of the second twitch to train-of-four stimulation, the study drug was administered according to group allocation. The plasma concentrations of rocuronium and sugammadex were serially measured at nine predefined time points following study drug administration. To determine efficacy, we measured the time elapsed from drug administration to recovery of T 4 /T 1 ≥ 0.9. For pharmacokinetics, non-compartmental analysis was performed and we monitored adverse event occurrence from the time of study drug administration until 24 h post-surgery. Results: Among the 29 enrolled participants, the sugammadex (2 mg/kg) and control groups showed recovery times [median (interquartile range)] of 1.3 (1.0–1.9) and 7.7 (5.3–21.0) min, respectively ( p = 0.002). There were no significant differences in recovery time among the participants in sugammadex groups. The pharmacokinetics of sugammadex were comparable to those of literature findings. Although two hypotensive events related to sugammadex were observed, no intervention was necessary. Conclusion: The findings of this pharmacokinetic analysis and efficacy study of sugammadex in Korean children indicated that sugammadex (2 mg/kg) may be safely administered for reversing moderate neuromuscular blockade. Some differences in pharmacokinetics of sugammadex were observed according to age. Clinical Trial Registration: http://clinicaltrials.gov (NCT04347486)" @default.
• W4365448858 created "2023-04-15" @default.
• W4365448858 creator A5010330867 @default.
• W4365448858 creator A5011226485 @default.
• W4365448858 creator A5014132243 @default.
• W4365448858 creator A5017969197 @default.
• W4365448858 creator A5033675001 @default.
• W4365448858 creator A5039850916 @default.
• W4365448858 creator A5056858852 @default.
• W4365448858 creator A5059501045 @default.
• W4365448858 creator A5085698562 @default.
• W4365448858 date "2023-04-13" @default.
• W4365448858 modified "2023-10-14" @default.
• W4365448858 title "Conventional reversal of rocuronium-induced neuromuscular blockade by sugammadex in Korean children: pharmacokinetics, efficacy, and safety analyses" @default.
• W4365448858 cites W1498584038 @default.
• W4365448858 cites W1972427477 @default.
• W4365448858 cites W1973589350 @default.
• W4365448858 cites W1982481750 @default.
• W4365448858 cites W2004638171 @default.
• W4365448858 cites W2014380000 @default.
• W4365448858 cites W2044367689 @default.
• W4365448858 cites W2064517847 @default.
• W4365448858 cites W2092759558 @default.
• W4365448858 cites W2113994462 @default.
• W4365448858 cites W2129726138 @default.
• W4365448858 cites W2157263718 @default.
• W4365448858 cites W2158196762 @default.
• W4365448858 cites W2161036875 @default.
• W4365448858 cites W2472037314 @default.
• W4365448858 cites W2512875740 @default.
• W4365448858 cites W2586436858 @default.
• W4365448858 cites W2734375642 @default.
• W4365448858 cites W2734760165 @default.
• W4365448858 cites W2803844903 @default.
• W4365448858 cites W2884222823 @default.
• W4365448858 cites W2888420502 @default.
• W4365448858 cites W2967651153 @default.
• W4365448858 cites W3002967723 @default.
• W4365448858 cites W3012967582 @default.
• W4365448858 cites W3122305730 @default.
• W4365448858 cites W4200113286 @default.
• W4365448858 cites W4242656301 @default.
• W4365448858 cites W4298326964 @default.
• W4365448858 doi "https://doi.org/10.3389/fphar.2023.1127932" @default.
• W4365448858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37124204" @default.
• W4365448858 hasPublicationYear "2023" @default.
• W4365448858 type Work @default.
• W4365448858 citedByCount "0" @default.
• W4365448858 crossrefType "journal-article" @default.
• W4365448858 hasAuthorship W4365448858A5010330867 @default.
• W4365448858 hasAuthorship W4365448858A5011226485 @default.
• W4365448858 hasAuthorship W4365448858A5014132243 @default.
• W4365448858 hasAuthorship W4365448858A5017969197 @default.
• W4365448858 hasAuthorship W4365448858A5033675001 @default.
• W4365448858 hasAuthorship W4365448858A5039850916 @default.
• W4365448858 hasAuthorship W4365448858A5056858852 @default.
• W4365448858 hasAuthorship W4365448858A5059501045 @default.
• W4365448858 hasAuthorship W4365448858A5085698562 @default.
• W4365448858 hasBestOaLocation W43654488581 @default.
• W4365448858 hasConcept C111113717 @default.
• W4365448858 hasConcept C112705442 @default.
• W4365448858 hasConcept C119060515 @default.
• W4365448858 hasConcept C141071460 @default.
• W4365448858 hasConcept C197934379 @default.
• W4365448858 hasConcept C2776277131 @default.
• W4365448858 hasConcept C2776988050 @default.
• W4365448858 hasConcept C2777411258 @default.
• W4365448858 hasConcept C2778560516 @default.
• W4365448858 hasConcept C2909465803 @default.
• W4365448858 hasConcept C42219234 @default.
• W4365448858 hasConcept C71924100 @default.
• W4365448858 hasConcept C98274493 @default.
• W4365448858 hasConceptScore W4365448858C111113717 @default.
• W4365448858 hasConceptScore W4365448858C112705442 @default.
• W4365448858 hasConceptScore W4365448858C119060515 @default.
• W4365448858 hasConceptScore W4365448858C141071460 @default.
• W4365448858 hasConceptScore W4365448858C197934379 @default.
• W4365448858 hasConceptScore W4365448858C2776277131 @default.
• W4365448858 hasConceptScore W4365448858C2776988050 @default.
• W4365448858 hasConceptScore W4365448858C2777411258 @default.
• W4365448858 hasConceptScore W4365448858C2778560516 @default.
• W4365448858 hasConceptScore W4365448858C2909465803 @default.
• W4365448858 hasConceptScore W4365448858C42219234 @default.
• W4365448858 hasConceptScore W4365448858C71924100 @default.
• W4365448858 hasConceptScore W4365448858C98274493 @default.
• W4365448858 hasFunder F4320322014 @default.
• W4365448858 hasLocation W43654488581 @default.
• W4365448858 hasLocation W43654488582 @default.
• W4365448858 hasLocation W43654488583 @default.
• W4365448858 hasOpenAccess W4365448858 @default.
• W4365448858 hasPrimaryLocation W43654488581 @default.
• W4365448858 hasRelatedWork W2011765774 @default.
• W4365448858 hasRelatedWork W2045103536 @default.
• W4365448858 hasRelatedWork W2114205538 @default.
• W4365448858 hasRelatedWork W2119616474 @default.
• W4365448858 hasRelatedWork W2183218377 @default.
• W4365448858 hasRelatedWork W2317046892 @default.
• W4365448858 hasRelatedWork W2322553135 @default.
• W4365448858 hasRelatedWork W2416776439 @default.
• W4365448858 hasRelatedWork W2789706405 @default.

• next