Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365452017> ?p ?o ?g. }
- W4365452017 endingPage "108740" @default.
- W4365452017 startingPage "108740" @default.
- W4365452017 abstract "Tocotrienols have strong antioxidant properties; however, tocotrienol has not been investigated in detail in aquatic products. In this study, the anti-inflammatory and antioxidant activities of the tocotrienol-rich fraction from rice bran oil and its potential mechanism were verified in a zebrafish CuSO4 inflammation model. The in vitro antioxidant activity was evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) stable radical method. The copper chelating activity was determined using the pyrocatechol violet method. Intracellular reactive oxygen species in zebrafish were detected using a fluorescent ROS probe. Transgenic Tg (lyz: DsRed2) zebrafish were used for neutrophil transmigration assays. The mRNA expression levels of antioxidant and pro-inflammatory factor genes were measured using quantitative real-time reverse transcription PCR. In the concentration range tested, 100 μg/mL TRF had the highest copper chelating activity (10%). TRF showed DPPH-free radical scavenging ability, which was 53% at 100 μg/mL TRF. TRF effectively repressed ROS generation and inhibited neutrophil migration to the inflamed site. Moreover, TRF upregulated the expression of antioxidant genes sod and gpx4b, inhibited the expression of pro-inflammatory factors tnfa and il8, and suppressed CuSO4-induced inflammation. In conclusion, TRF has significant anti-inflammatory and antioxidant properties, which supports the use of TRF as an aquatic feed additive to improve the anti-inflammatory and antioxidant capacity of aquatic products." @default.
- W4365452017 created "2023-04-15" @default.
- W4365452017 creator A5009286692 @default.
- W4365452017 creator A5011254279 @default.
- W4365452017 creator A5014557820 @default.
- W4365452017 creator A5027958721 @default.
- W4365452017 creator A5036609490 @default.
- W4365452017 creator A5051439492 @default.
- W4365452017 creator A5056672927 @default.
- W4365452017 creator A5065605022 @default.
- W4365452017 creator A5071037763 @default.
- W4365452017 creator A5078246846 @default.
- W4365452017 creator A5084805165 @default.
- W4365452017 creator A5084890604 @default.
- W4365452017 date "2023-05-01" @default.
- W4365452017 modified "2023-10-16" @default.
- W4365452017 title "Anti-inflammatory and antioxidant properties of rice bran oil extract in copper sulfate-induced inflammation in zebrafish (Danio rerio)" @default.
- W4365452017 cites W1870697530 @default.
- W4365452017 cites W1898569975 @default.
- W4365452017 cites W1965390881 @default.
- W4365452017 cites W1983135948 @default.
- W4365452017 cites W1996649210 @default.
- W4365452017 cites W1997979602 @default.
- W4365452017 cites W2007205248 @default.
- W4365452017 cites W2011212271 @default.
- W4365452017 cites W2015319106 @default.
- W4365452017 cites W2031200260 @default.
- W4365452017 cites W2052084403 @default.
- W4365452017 cites W2055009682 @default.
- W4365452017 cites W2065276108 @default.
- W4365452017 cites W2071963896 @default.
- W4365452017 cites W2075267139 @default.
- W4365452017 cites W2084141237 @default.
- W4365452017 cites W2097481089 @default.
- W4365452017 cites W2107277218 @default.
- W4365452017 cites W2156962391 @default.
- W4365452017 cites W2187931582 @default.
- W4365452017 cites W2270295445 @default.
- W4365452017 cites W2274298943 @default.
- W4365452017 cites W2331176038 @default.
- W4365452017 cites W2464625649 @default.
- W4365452017 cites W2530853774 @default.
- W4365452017 cites W2592737986 @default.
- W4365452017 cites W2600990049 @default.
- W4365452017 cites W2761282678 @default.
- W4365452017 cites W2768448944 @default.
- W4365452017 cites W2771024508 @default.
- W4365452017 cites W2781863420 @default.
- W4365452017 cites W2782954296 @default.
- W4365452017 cites W2784202279 @default.
- W4365452017 cites W2789925679 @default.
- W4365452017 cites W2800493856 @default.
- W4365452017 cites W2902869582 @default.
- W4365452017 cites W2916919652 @default.
- W4365452017 cites W2917639656 @default.
- W4365452017 cites W2919001325 @default.
- W4365452017 cites W3007281303 @default.
- W4365452017 cites W3011025968 @default.
- W4365452017 cites W3210250312 @default.
- W4365452017 cites W3216930162 @default.
- W4365452017 cites W3217808405 @default.
- W4365452017 cites W4206997428 @default.
- W4365452017 cites W4207025870 @default.
- W4365452017 cites W4213257562 @default.
- W4365452017 cites W4223446645 @default.
- W4365452017 cites W4223501040 @default.
- W4365452017 cites W4319298546 @default.
- W4365452017 doi "https://doi.org/10.1016/j.fsi.2023.108740" @default.
- W4365452017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37061070" @default.
- W4365452017 hasPublicationYear "2023" @default.
- W4365452017 type Work @default.
- W4365452017 citedByCount "2" @default.
- W4365452017 countsByYear W43654520172023 @default.
- W4365452017 crossrefType "journal-article" @default.
- W4365452017 hasAuthorship W4365452017A5009286692 @default.
- W4365452017 hasAuthorship W4365452017A5011254279 @default.
- W4365452017 hasAuthorship W4365452017A5014557820 @default.
- W4365452017 hasAuthorship W4365452017A5027958721 @default.
- W4365452017 hasAuthorship W4365452017A5036609490 @default.
- W4365452017 hasAuthorship W4365452017A5051439492 @default.
- W4365452017 hasAuthorship W4365452017A5056672927 @default.
- W4365452017 hasAuthorship W4365452017A5065605022 @default.
- W4365452017 hasAuthorship W4365452017A5071037763 @default.
- W4365452017 hasAuthorship W4365452017A5078246846 @default.
- W4365452017 hasAuthorship W4365452017A5084805165 @default.
- W4365452017 hasAuthorship W4365452017A5084890604 @default.
- W4365452017 hasConcept C104317684 @default.
- W4365452017 hasConcept C153911025 @default.
- W4365452017 hasConcept C185592680 @default.
- W4365452017 hasConcept C18903297 @default.
- W4365452017 hasConcept C203014093 @default.
- W4365452017 hasConcept C206139338 @default.
- W4365452017 hasConcept C2776873940 @default.
- W4365452017 hasConcept C2776878037 @default.
- W4365452017 hasConcept C2776914184 @default.
- W4365452017 hasConcept C2778004101 @default.
- W4365452017 hasConcept C2781401929 @default.
- W4365452017 hasConcept C48349386 @default.