Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365459502> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4365459502 endingPage "12" @default.
- W4365459502 startingPage "1" @default.
- W4365459502 abstract "Epigenetic has been implicated in pulmonary fibrosis. However, there is limited information regarding the biological role of the epigenetic reader MeCP2 in pulmonary fibrosis. The aim of this study was to investigate the role of MeCP2 and its target WIF1 in pulmonary fibrosis. The pathological changes and collagen depositions was analyzed by H&E, Masson’s Trichrome Staining and Sirius Red staining. MeCP2, WIF1, α-SMA, Wnt1, β-catenin, and collagen I expression were analyzed by western blotting, RT-qPCR, immunohistochemistry, immunofluorescence, respectively. The effects of MeCP2 on pulmonary fibrosis involve epigenetic mechanisms, using cultured cells, animal models, and clinical samples. Herein, our results indicated that MeCP2 level was up-regulated, while WIF1 was decreased in Bleomycin (BLM)-induced mice pulmonary fibrosis tissues, patients pulmonary fibrosis tissues and TGF-β1-induced lung fibroblast. Knockdown of MeCP2 by siRNA can rescue WIF1 downregulation in TGF-β1-induced lung fibroblast, inhibited lung fibroblast activation. The DNA methylation inhibitor 5-azadC-treated lung fibroblasts have increased WIF1 expression with reduced MeCP2 association. In addition, we found that reduced expression of WIF1 caused by TGF-β1 is associated with the promoter methylation status of WIF1. Moreover, in vivo studies revealed that knockdown of MeCP2 mice exhibited significantly ameliorated pulmonary fibrosis, decreased interstitial collagen deposition, and increased WIF1 expression. Taken together, our study showed that epigenetic reader MeCP2 repressed WIF1 facilitates lung fibroblast proliferation, migration and pulmonary fibrosis." @default.
- W4365459502 created "2023-04-15" @default.
- W4365459502 creator A5001172008 @default.
- W4365459502 creator A5022802322 @default.
- W4365459502 creator A5043719360 @default.
- W4365459502 creator A5050388054 @default.
- W4365459502 creator A5059476293 @default.
- W4365459502 creator A5063576337 @default.
- W4365459502 creator A5089528237 @default.
- W4365459502 creator A5038165529 @default.
- W4365459502 date "2023-05-01" @default.
- W4365459502 modified "2023-10-05" @default.
- W4365459502 title "Epigenetic reader MeCP2 repressed WIF1 boosts lung fibroblast proliferation, migration and pulmonary fibrosis" @default.
- W4365459502 cites W1999079520 @default.
- W4365459502 cites W2002587076 @default.
- W4365459502 cites W2022370858 @default.
- W4365459502 cites W2056918422 @default.
- W4365459502 cites W2124832584 @default.
- W4365459502 cites W2151357246 @default.
- W4365459502 cites W2168555507 @default.
- W4365459502 cites W2173474465 @default.
- W4365459502 cites W2332592059 @default.
- W4365459502 cites W2471236541 @default.
- W4365459502 cites W2605407336 @default.
- W4365459502 cites W2755967972 @default.
- W4365459502 cites W2765650816 @default.
- W4365459502 cites W2967460951 @default.
- W4365459502 cites W3045466751 @default.
- W4365459502 cites W3082487188 @default.
- W4365459502 cites W3092826551 @default.
- W4365459502 cites W3183537513 @default.
- W4365459502 cites W3184451296 @default.
- W4365459502 cites W4200319331 @default.
- W4365459502 cites W4200524915 @default.
- W4365459502 cites W4210580784 @default.
- W4365459502 cites W4210998775 @default.
- W4365459502 cites W4221021846 @default.
- W4365459502 cites W4231676654 @default.
- W4365459502 doi "https://doi.org/10.1016/j.toxlet.2023.04.004" @default.
- W4365459502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37061208" @default.
- W4365459502 hasPublicationYear "2023" @default.
- W4365459502 type Work @default.
- W4365459502 citedByCount "0" @default.
- W4365459502 crossrefType "journal-article" @default.
- W4365459502 hasAuthorship W4365459502A5001172008 @default.
- W4365459502 hasAuthorship W4365459502A5022802322 @default.
- W4365459502 hasAuthorship W4365459502A5038165529 @default.
- W4365459502 hasAuthorship W4365459502A5043719360 @default.
- W4365459502 hasAuthorship W4365459502A5050388054 @default.
- W4365459502 hasAuthorship W4365459502A5059476293 @default.
- W4365459502 hasAuthorship W4365459502A5063576337 @default.
- W4365459502 hasAuthorship W4365459502A5089528237 @default.
- W4365459502 hasConcept C104317684 @default.
- W4365459502 hasConcept C142724271 @default.
- W4365459502 hasConcept C2779770810 @default.
- W4365459502 hasConcept C2780381497 @default.
- W4365459502 hasConcept C2780559512 @default.
- W4365459502 hasConcept C2781244666 @default.
- W4365459502 hasConcept C41091548 @default.
- W4365459502 hasConcept C502942594 @default.
- W4365459502 hasConcept C54355233 @default.
- W4365459502 hasConcept C55493867 @default.
- W4365459502 hasConcept C71924100 @default.
- W4365459502 hasConcept C81885089 @default.
- W4365459502 hasConcept C86803240 @default.
- W4365459502 hasConceptScore W4365459502C104317684 @default.
- W4365459502 hasConceptScore W4365459502C142724271 @default.
- W4365459502 hasConceptScore W4365459502C2779770810 @default.
- W4365459502 hasConceptScore W4365459502C2780381497 @default.
- W4365459502 hasConceptScore W4365459502C2780559512 @default.
- W4365459502 hasConceptScore W4365459502C2781244666 @default.
- W4365459502 hasConceptScore W4365459502C41091548 @default.
- W4365459502 hasConceptScore W4365459502C502942594 @default.
- W4365459502 hasConceptScore W4365459502C54355233 @default.
- W4365459502 hasConceptScore W4365459502C55493867 @default.
- W4365459502 hasConceptScore W4365459502C71924100 @default.
- W4365459502 hasConceptScore W4365459502C81885089 @default.
- W4365459502 hasConceptScore W4365459502C86803240 @default.
- W4365459502 hasFunder F4320321603 @default.
- W4365459502 hasLocation W43654595021 @default.
- W4365459502 hasLocation W43654595022 @default.
- W4365459502 hasOpenAccess W4365459502 @default.
- W4365459502 hasPrimaryLocation W43654595021 @default.
- W4365459502 hasRelatedWork W2011156896 @default.
- W4365459502 hasRelatedWork W2140217617 @default.
- W4365459502 hasRelatedWork W2282605689 @default.
- W4365459502 hasRelatedWork W2354632479 @default.
- W4365459502 hasRelatedWork W2359423365 @default.
- W4365459502 hasRelatedWork W2361968815 @default.
- W4365459502 hasRelatedWork W2377674023 @default.
- W4365459502 hasRelatedWork W2379755408 @default.
- W4365459502 hasRelatedWork W2463729464 @default.
- W4365459502 hasRelatedWork W2596596967 @default.
- W4365459502 hasVolume "381" @default.
- W4365459502 isParatext "false" @default.
- W4365459502 isRetracted "false" @default.
- W4365459502 workType "article" @default.