Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365479408> ?p ?o ?g. }
- W4365479408 endingPage "1823" @default.
- W4365479408 startingPage "1811" @default.
- W4365479408 abstract "This prospective study aimed to investigate the prognostic effect of sarcopenia, geriatric, and nutritional status in older patients with diffuse large B-cell lymphoma (DLBCL). Ninety-five patients with DLBCL older than 70 years who were treated with immunochemotherapy were included. The lumbar L3 skeletal muscle index (L3-SMI) was measured by computed tomography at baseline, and sarcopenia was defined as low L3-SMI. Geriatric assessment included G8 score, CIRS-G scale, Timed Up and Go test, and instrumental activity of daily living. Nutritional status was assessed using the Mini Nutritional Assessment and the body mass index, and several scores used in the literature incorporating nutritional and inflammatory biomarkers, namely the Nutritional and inflammatory status (NIS), Geriatric Nutritional Risk Index, Prognostic Nutritional Index, and Glasgow Prognostic Score.Fifty-three patients were considered sarcopenic. Sarcopenic patients displayed higher levels of inflammation markers and lower levels of prealbumin than non-sarcopenic patients. Sarcopenia was associated with NIS, but was not associated with severe adverse events and treatment disruptions. They were, however, more frequent among patients with elevated NIS. Sarcopenia did not appear in this study as a prognostic factor for progression-free survival (PFS) or overall survival (OS). However, NIS emerged as predictive of the outcome with a 2-year PFS rate of 88% in the NIS ≤ 1 group and 49% in the NIS > 1 group and a significant effect in a multivariate analysis for both PFS (p = 0.049) and OS (HR = 9.61, CI 95% = [1.03-89.66], p = 0.04). Sarcopenia was not associated with adverse outcomes, but was related to NIS, which appeared to be an independent prognostic factor." @default.
- W4365479408 created "2023-04-15" @default.
- W4365479408 creator A5003078312 @default.
- W4365479408 creator A5010787020 @default.
- W4365479408 creator A5014930887 @default.
- W4365479408 creator A5019451763 @default.
- W4365479408 creator A5027818597 @default.
- W4365479408 creator A5040148300 @default.
- W4365479408 creator A5040357157 @default.
- W4365479408 creator A5043479613 @default.
- W4365479408 creator A5043543553 @default.
- W4365479408 creator A5060848089 @default.
- W4365479408 creator A5061006030 @default.
- W4365479408 creator A5062422990 @default.
- W4365479408 creator A5064821481 @default.
- W4365479408 creator A5066990893 @default.
- W4365479408 creator A5069409600 @default.
- W4365479408 creator A5071223580 @default.
- W4365479408 creator A5072059450 @default.
- W4365479408 creator A5072644037 @default.
- W4365479408 creator A5080350693 @default.
- W4365479408 creator A5082700087 @default.
- W4365479408 creator A5088236659 @default.
- W4365479408 date "2023-04-14" @default.
- W4365479408 modified "2023-09-26" @default.
- W4365479408 title "Prognostic relevance of sarcopenia, geriatric, and nutritional assessments in older patients with diffuse large B-cell lymphoma: results of a multicentric prospective cohort study" @default.
- W4365479408 cites W1456239636 @default.
- W4365479408 cites W1507637529 @default.
- W4365479408 cites W1521873730 @default.
- W4365479408 cites W1817151680 @default.
- W4365479408 cites W1934992232 @default.
- W4365479408 cites W1958916249 @default.
- W4365479408 cites W1966544892 @default.
- W4365479408 cites W1974704788 @default.
- W4365479408 cites W1976175768 @default.
- W4365479408 cites W1981954235 @default.
- W4365479408 cites W1987760772 @default.
- W4365479408 cites W1992234322 @default.
- W4365479408 cites W2005579966 @default.
- W4365479408 cites W2015420121 @default.
- W4365479408 cites W2035098923 @default.
- W4365479408 cites W2045022582 @default.
- W4365479408 cites W2055782633 @default.
- W4365479408 cites W2057221507 @default.
- W4365479408 cites W2067043232 @default.
- W4365479408 cites W2082755106 @default.
- W4365479408 cites W2094141634 @default.
- W4365479408 cites W2097022747 @default.
- W4365479408 cites W2099214237 @default.
- W4365479408 cites W2101398993 @default.
- W4365479408 cites W2103099593 @default.
- W4365479408 cites W2108349450 @default.
- W4365479408 cites W2116432054 @default.
- W4365479408 cites W2129337227 @default.
- W4365479408 cites W2129827192 @default.
- W4365479408 cites W2131424155 @default.
- W4365479408 cites W2131591460 @default.
- W4365479408 cites W2136621779 @default.
- W4365479408 cites W2141955497 @default.
- W4365479408 cites W2147112454 @default.
- W4365479408 cites W2151798996 @default.
- W4365479408 cites W2158649954 @default.
- W4365479408 cites W2159725313 @default.
- W4365479408 cites W2160293835 @default.
- W4365479408 cites W2163709153 @default.
- W4365479408 cites W2286776653 @default.
- W4365479408 cites W2396623636 @default.
- W4365479408 cites W2460765285 @default.
- W4365479408 cites W2474287722 @default.
- W4365479408 cites W2481571837 @default.
- W4365479408 cites W2554824743 @default.
- W4365479408 cites W2598425552 @default.
- W4365479408 cites W2605850735 @default.
- W4365479408 cites W2606295944 @default.
- W4365479408 cites W2753952666 @default.
- W4365479408 cites W2767055970 @default.
- W4365479408 cites W2900243967 @default.
- W4365479408 cites W2906970549 @default.
- W4365479408 cites W2920382480 @default.
- W4365479408 cites W2928026341 @default.
- W4365479408 cites W2936973290 @default.
- W4365479408 cites W2950250635 @default.
- W4365479408 cites W2951995922 @default.
- W4365479408 cites W2966550263 @default.
- W4365479408 cites W3011183352 @default.
- W4365479408 cites W3015658797 @default.
- W4365479408 cites W3016040335 @default.
- W4365479408 cites W3025041434 @default.
- W4365479408 cites W3026334608 @default.
- W4365479408 cites W3088165091 @default.
- W4365479408 cites W3111965232 @default.
- W4365479408 cites W3120715707 @default.
- W4365479408 cites W3127059308 @default.
- W4365479408 cites W3136678199 @default.
- W4365479408 cites W3157203311 @default.
- W4365479408 cites W4200303223 @default.
- W4365479408 cites W4210276894 @default.
- W4365479408 cites W4214479978 @default.