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- W4365482885 abstract "To investigate whether the gut microbiota differs in patients with chronic kidney disease receiving kidney transplant or hemodialysis, and to explore the relationship between the gut microbiota and clinical indicators.A total of 72 patients with kidney transplantation (RT) and 78 patients with hemodialysis (HD) admitted to the First Affiliated Hospital of Soochow University from January 2019 to October 2022 were selected as the research subjects. The V3-V4 region sequences of 16S rRNA were used for high-throughput sequencing to analyze the differences in gut microbiome between the two groups and its relationship with clinical indicators.Gut microbial α diversity (Chao1, Ace, Shannon, Simpson) was significantly decreased in RT patients compared with that in HD patients (P<0.05). The relative abundance of Bacteroides, Megamonas, and Prevotella was significantly higher in HD patients than that in RT patients (P<0.05). There was a negative association between the Bacteroides and β2-microglobulin (β2-MG) (P<0.05). Lactobacillus was negatively correlated with uric acid (UA) (P<0.05).This study elucidates the composition and changes of the gut microbiota in RT and HD patients and its association with clinical indicators, providing a scientific basis for the regulatory mechanism of gut microbiota in the treatment of chronic kidney disease." @default.
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- W4365482885 date "2023-01-01" @default.
- W4365482885 modified "2023-10-16" @default.
- W4365482885 title "A cross-sectional study on gut microbiota in patients with chronic kidney disease undergoing kidney transplant or hemodialysis." @default.
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