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• W4365505055 abstract "Oxytetracycline (OTC), a widely used antibiotic that is readily detectable in the environment, potentially has a number of negative ecological consequences. The present study revealed the key role of the cometabolic breakdown of OTC in activated sludge microbiomes, which led to a high removal efficiency and detoxification of both OTC and its derivatives. An AS bioreactor was established to treat environmentally relevant levels of OTC. The bioreactor achieved an overall OTC removal efficiency of 94–97% at the steady state, with cometabolic biotransformation as the primary contributor to this ahead of other removal routes such as direct metabolic biodegradation, biosorption, and phosphorolysis. A novel biotransformation pathway for OTC proposed in this study involved dehydration, hydroxylation, ring cleavage, and alcohol dehydrogenation, distinguishing it from previously reported pathways. Although transformation products with potentially higher toxicity than OTC formed during the biotransformation process, the AS microbiome eliminated the overall toxicity of both OTC and its derivatives, as illustrated by both molecular structure-based toxicity simulations and antimicrobial susceptibility testing. Analysis of microbiome sequence data revealed the bacterial populations potentially facilitating cometabolic (e.g., Tolumonas) and direct metabolic (e.g., Flavobacterium) biotransformation. Overall, our study provides new insights into the removal routes and kinetics for OTC in AS microbiomes and the key species that potentially promote OTC transformation and detoxification." @default.
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• W4365505055 date "2023-06-01" @default.
• W4365505055 modified "2023-10-14" @default.
• W4365505055 title "Cometabolic biotransformation mediates the detoxification of oxytetracycline in Flavobacterium-enriched microbiome" @default.
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• W4365505055 doi "https://doi.org/10.1016/j.jece.2023.109932" @default.
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