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- W4365510988 abstract "<ns4:p><ns4:bold>Introduction:</ns4:bold> <ns4:italic>Grapsus albolineatus</ns4:italic> is thought to have a high concentration of carotenoid pigments. Although studies on male <ns4:italic>G. albolineatus</ns4:italic> have been conducted, no studies on pigment extraction from female <ns4:italic>G. albolineatus</ns4:italic> have been carried out. Carotenoids have a high ability to fight free radicals. Previous research has shown that carotenoids can fight free radicals that cause premature skin-aging.</ns4:p><ns4:p> <ns4:bold>Aim</ns4:bold>: The purpose of this research was to find out what kinds of carotenoids are found in <ns4:italic>G. albolineatus</ns4:italic> and whether they can act as natural inhibitors of proteins that cause premature aging, such as glucogenase, elastase, and hyaluronidase enzymes.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Carotenoids were extracted from <ns4:italic>G. albolineatus</ns4:italic> using column chromatography and high-performance liquid chromatography (HPLC); molecular docking and visualization were done with Autodock 4.2 and Discovery Studio/Biovia, respectively. </ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>According to HPLC data, there are carotenoid pigments such as didehydroastaxanthin, tetrahydroastaxanthin, dihydroastaxanthin, diatoxanthin, astaxanthin, and adonixanthin. According to molecular docking experiments, pigment carotenoids from <ns4:italic>G. albolineatus</ns4:italic> are efficient inhibitors of protein elastase and hyaluronidase with binding energy range -7.58 kcal/mol <ns4:italic>-</ns4:italic> -9.03 kcal/mol and -6.16 kcal/mol <ns4:italic>-</ns4:italic> -7.71 kcal/mol, respectively.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> <ns4:italic>G. albolineatus</ns4:italic> carotenoids have the potential to be anti-aging since they are more effective as protein elastase and hyaluronidase inhibitors than their native inhibitors.</ns4:p>" @default.
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- W4365510988 date "2023-04-14" @default.
- W4365510988 modified "2023-10-17" @default.
- W4365510988 title "Carotenoids from female Grapsus albolineatus as potential anti-ageing compounds" @default.
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- W4365510988 doi "https://doi.org/10.12688/f1000research.122649.2" @default.
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