Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365514990> ?p ?o ?g. }
- W4365514990 endingPage "7235" @default.
- W4365514990 startingPage "7235" @default.
- W4365514990 abstract "Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer development and progression, and epigenetic-targeting drugs such as DNA methyltransferase inhibitors, histone-modifying enzymes, and mRNA regulators (such as miRNA mimics and antagomiRs) can reverse these alterations. Therefore, these epigenetic-targeting drugs are promising candidates for cancer treatment. However, there is currently no effective epi-drug monotherapy for breast cancer. Combining epigenetic drugs with conventional therapies has yielded positive outcomes and may be a promising strategy for breast cancer therapy. DNA methyltransferase inhibitors, such as azacitidine, and histone deacetylase inhibitors, such as vorinostat, have been used in combination with chemotherapy to treat breast cancer. miRNA regulators, such as miRNA mimics and antagomiRs, can alter the expression of specific genes involved in cancer development. miRNA mimics, such as miR-34, have been used to inhibit tumor growth, while antagomiRs, such as anti-miR-10b, have been used to inhibit metastasis. The development of epi-drugs that target specific epigenetic changes may lead to more effective monotherapy options in the future." @default.
- W4365514990 created "2023-04-15" @default.
- W4365514990 creator A5033609547 @default.
- W4365514990 creator A5053003398 @default.
- W4365514990 creator A5064187635 @default.
- W4365514990 creator A5080341246 @default.
- W4365514990 creator A5086464692 @default.
- W4365514990 date "2023-04-13" @default.
- W4365514990 modified "2023-10-17" @default.
- W4365514990 title "Harnessing Epigenetics for Breast Cancer Therapy: The Role of DNA Methylation, Histone Modifications, and MicroRNA" @default.
- W4365514990 cites W1486099519 @default.
- W4365514990 cites W1487070667 @default.
- W4365514990 cites W1658127082 @default.
- W4365514990 cites W1965778700 @default.
- W4365514990 cites W1967064280 @default.
- W4365514990 cites W1969201755 @default.
- W4365514990 cites W1969559178 @default.
- W4365514990 cites W1971156834 @default.
- W4365514990 cites W1971382122 @default.
- W4365514990 cites W1972250842 @default.
- W4365514990 cites W1974167857 @default.
- W4365514990 cites W1974360536 @default.
- W4365514990 cites W1976285590 @default.
- W4365514990 cites W1980937575 @default.
- W4365514990 cites W1984608562 @default.
- W4365514990 cites W1986586739 @default.
- W4365514990 cites W1989949054 @default.
- W4365514990 cites W1994455902 @default.
- W4365514990 cites W1998865079 @default.
- W4365514990 cites W1999825155 @default.
- W4365514990 cites W2004824814 @default.
- W4365514990 cites W2007558412 @default.
- W4365514990 cites W2010660857 @default.
- W4365514990 cites W2013039468 @default.
- W4365514990 cites W2013250198 @default.
- W4365514990 cites W2013435275 @default.
- W4365514990 cites W2014194530 @default.
- W4365514990 cites W2015893546 @default.
- W4365514990 cites W2016168309 @default.
- W4365514990 cites W2025843833 @default.
- W4365514990 cites W2025998934 @default.
- W4365514990 cites W2030555961 @default.
- W4365514990 cites W2031087599 @default.
- W4365514990 cites W2033150108 @default.
- W4365514990 cites W2035243232 @default.
- W4365514990 cites W2039135884 @default.
- W4365514990 cites W2040143218 @default.
- W4365514990 cites W2042978168 @default.
- W4365514990 cites W2043179106 @default.
- W4365514990 cites W2045986053 @default.
- W4365514990 cites W2048386285 @default.
- W4365514990 cites W2050448117 @default.
- W4365514990 cites W2050875047 @default.
- W4365514990 cites W2058484429 @default.
- W4365514990 cites W2061205787 @default.
- W4365514990 cites W2067968965 @default.
- W4365514990 cites W2068351971 @default.
- W4365514990 cites W2073727437 @default.
- W4365514990 cites W2076350348 @default.
- W4365514990 cites W2076956902 @default.
- W4365514990 cites W2077724220 @default.
- W4365514990 cites W2086492419 @default.
- W4365514990 cites W2087073159 @default.
- W4365514990 cites W2089258089 @default.
- W4365514990 cites W2092670649 @default.
- W4365514990 cites W2093385884 @default.
- W4365514990 cites W2095776988 @default.
- W4365514990 cites W2096330673 @default.
- W4365514990 cites W2096598880 @default.
- W4365514990 cites W2097180978 @default.
- W4365514990 cites W2100385616 @default.
- W4365514990 cites W2102169774 @default.
- W4365514990 cites W2102650381 @default.
- W4365514990 cites W2102685625 @default.
- W4365514990 cites W2102850127 @default.
- W4365514990 cites W2104591325 @default.
- W4365514990 cites W2105835610 @default.
- W4365514990 cites W2107089026 @default.
- W4365514990 cites W2107846614 @default.
- W4365514990 cites W2110957729 @default.
- W4365514990 cites W2111234709 @default.
- W4365514990 cites W2113219587 @default.
- W4365514990 cites W2114027903 @default.
- W4365514990 cites W2116107149 @default.
- W4365514990 cites W2117499849 @default.
- W4365514990 cites W2119088658 @default.
- W4365514990 cites W2119557776 @default.
- W4365514990 cites W2120084347 @default.
- W4365514990 cites W2120905843 @default.
- W4365514990 cites W2122321093 @default.
- W4365514990 cites W2124268899 @default.
- W4365514990 cites W2124621227 @default.
- W4365514990 cites W2124679827 @default.
- W4365514990 cites W2127289529 @default.
- W4365514990 cites W2127738922 @default.
- W4365514990 cites W2127967682 @default.
- W4365514990 cites W2128199918 @default.
- W4365514990 cites W2128815309 @default.