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- W4365515369 abstract "Epithelial-mesenchymal transition (EMT), which is well known for its role in embryonic development, malignant transformation, and tumor progression, has also been implicated in a variety of retinal diseases, including proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), and diabetic retinopathy. EMT of the retinal pigment epithelium (RPE), although important in the pathogenesis of these retinal conditions, is not well understood at the molecular level. We and others have shown that a variety of molecules, including the co-treatment of human stem cell-derived RPE monolayer cultures with transforming growth factor beta (TGF–β) and the inflammatory cytokine tumor necrosis factor alpha (TNF–α), can induce RPE–EMT; however, small molecule inhibitors of RPE–EMT have been less well studied. Here, we demonstrate that BAY651942, a small molecule inhibitor of nuclear factor kapa-B kinase subunit beta (IKKβ) that selectively targets NF-κB signaling, can modulate TGF–β/TNF–α-induced RPE–EMT. Next, we performed RNA-seq studies on BAY651942 treated hRPE monolayers to dissect altered biological pathways and signaling events. Further, we validated the effect of IKKβ inhibition on RPE–EMT-associated factors using a second IKKβ inhibitor, BMS345541, with RPE monolayers derived from an independent stem cell line. Our data highlights the fact that pharmacological inhibition of RPE–EMT restores RPE identity and may provide a promising approach for treating retinal diseases that involve RPE dedifferentiation and EMT." @default.
- W4365515369 created "2023-04-15" @default.
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- W4365515369 date "2023-04-13" @default.
- W4365515369 modified "2023-10-15" @default.
- W4365515369 title "IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium" @default.
- W4365515369 cites W1527949842 @default.
- W4365515369 cites W1534551308 @default.
- W4365515369 cites W1577577364 @default.
- W4365515369 cites W1593721266 @default.
- W4365515369 cites W1960434785 @default.
- W4365515369 cites W1963811831 @default.
- W4365515369 cites W1964847767 @default.
- W4365515369 cites W1965031576 @default.
- W4365515369 cites W1966701340 @default.
- W4365515369 cites W1968730445 @default.
- W4365515369 cites W1977000581 @default.
- W4365515369 cites W1978500715 @default.
- W4365515369 cites W1979520552 @default.
- W4365515369 cites W1980768491 @default.
- W4365515369 cites W1981158116 @default.
- W4365515369 cites W2002712265 @default.
- W4365515369 cites W2011041372 @default.
- W4365515369 cites W2012322597 @default.
- W4365515369 cites W2014677321 @default.
- W4365515369 cites W2021788996 @default.
- W4365515369 cites W2031863655 @default.
- W4365515369 cites W2038969444 @default.
- W4365515369 cites W2050991107 @default.
- W4365515369 cites W2060357236 @default.
- W4365515369 cites W2074258134 @default.
- W4365515369 cites W2074643756 @default.
- W4365515369 cites W2075936537 @default.
- W4365515369 cites W2103434485 @default.
- W4365515369 cites W2105315497 @default.
- W4365515369 cites W2106877484 @default.
- W4365515369 cites W2111274886 @default.
- W4365515369 cites W2114914263 @default.
- W4365515369 cites W2122734862 @default.
- W4365515369 cites W2124343538 @default.
- W4365515369 cites W2130050140 @default.
- W4365515369 cites W2130775876 @default.
- W4365515369 cites W2133556048 @default.
- W4365515369 cites W2137138278 @default.
- W4365515369 cites W2138818791 @default.
- W4365515369 cites W2140551998 @default.
- W4365515369 cites W2140729960 @default.
- W4365515369 cites W2141290206 @default.
- W4365515369 cites W2141458291 @default.
- W4365515369 cites W2145683111 @default.
- W4365515369 cites W2156123914 @default.
- W4365515369 cites W2159128306 @default.
- W4365515369 cites W2159979956 @default.
- W4365515369 cites W2162143298 @default.
- W4365515369 cites W2165838325 @default.
- W4365515369 cites W2170486071 @default.
- W4365515369 cites W2195792341 @default.
- W4365515369 cites W2197312515 @default.
- W4365515369 cites W2233221674 @default.
- W4365515369 cites W2286612125 @default.
- W4365515369 cites W2330912841 @default.
- W4365515369 cites W2347205644 @default.
- W4365515369 cites W2409025151 @default.
- W4365515369 cites W2462302216 @default.
- W4365515369 cites W2591749400 @default.
- W4365515369 cites W2748749105 @default.
- W4365515369 cites W2783919423 @default.
- W4365515369 cites W2795493536 @default.
- W4365515369 cites W2797486746 @default.
- W4365515369 cites W2800526675 @default.
- W4365515369 cites W2807917362 @default.
- W4365515369 cites W2887977772 @default.
- W4365515369 cites W2896480433 @default.
- W4365515369 cites W2900569176 @default.
- W4365515369 cites W2901068426 @default.
- W4365515369 cites W3004470483 @default.
- W4365515369 cites W3014869565 @default.
- W4365515369 cites W3016840787 @default.
- W4365515369 cites W3035600038 @default.
- W4365515369 cites W3037858919 @default.
- W4365515369 cites W3100546845 @default.
- W4365515369 cites W3142774132 @default.
- W4365515369 cites W3164918554 @default.
- W4365515369 cites W3183866489 @default.
- W4365515369 cites W3193777758 @default.
- W4365515369 cites W3195088730 @default.