FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365515710> ?p ?o ?g. }

• W4365515710 abstract "Detailed analyses of genetic diversity, antigenic variability, protein localization and immunological responses are vital for the prioritization of novel malaria vaccine candidates. Comprehensive approaches to determine the most appropriate antigen variants needed to provide broad protection are challenging and consequently rarely undertaken.Here, we characterized PF3D7_1136200, which we named Asparagine-Rich Merozoite Antigen (ARMA) based on the analysis of its sequence, localization and immunogenicity. We analyzed IgG and IgM responses against the common variants of ARMA in independent prospective cohort studies in Burkina Faso (N = 228), Kenya (N = 252) and Mali (N = 195) using a custom microarray, Div-KILCHIP.We found a marked population structure between parasites from Africa and Asia. African isolates shared 34 common haplotypes, including a dominant pair although the overall selection pressure was directional (Tajima's D = -2.57; Fu and Li's F = -9.69; P < 0.02). ARMA was localized to the merozoite surface, IgG antibodies induced Fc-mediated degranulation of natural killer cells and strongly inhibited parasite growth in vitro. We found profound serological diversity, but IgG and IgM responses were highly correlated and a hierarchical clustering analysis identified only three major serogroups. Protective IgG and IgM antibodies appeared to target both cross-reactive and distinct epitopes across variants. However, combinations of IgG and IgM antibodies against selected variants were associated with complete protection against clinical episodes of malaria.Our systematic strategy exploits genomic data to deduce the handful of antigen variants with the strongest potential to induce broad protection and may be broadly applicable to other complex pathogens for which effective vaccines remain elusive." @default.
• W4365515710 created "2023-04-15" @default.
• W4365515710 creator A5004418767 @default.
• W4365515710 creator A5011999400 @default.
• W4365515710 creator A5013139296 @default.
• W4365515710 creator A5013961861 @default.
• W4365515710 creator A5015868385 @default.
• W4365515710 creator A5024769478 @default.
• W4365515710 creator A5026079900 @default.
• W4365515710 creator A5030014328 @default.
• W4365515710 creator A5031234640 @default.
• W4365515710 creator A5032797803 @default.
• W4365515710 creator A5040533373 @default.
• W4365515710 creator A5055908384 @default.
• W4365515710 creator A5057250881 @default.
• W4365515710 creator A5059822645 @default.
• W4365515710 creator A5069843611 @default.
• W4365515710 creator A5087983235 @default.
• W4365515710 date "2023-04-14" @default.
• W4365515710 modified "2023-10-17" @default.
• W4365515710 title "Characterization of a novel Plasmodium falciparum merozoite surface antigen and potential vaccine target" @default.
• W4365515710 cites W1946252112 @default.
• W4365515710 cites W1967304374 @default.
• W4365515710 cites W1971747284 @default.
• W4365515710 cites W1973603244 @default.
• W4365515710 cites W1979346865 @default.
• W4365515710 cites W2006741973 @default.
• W4365515710 cites W2009959065 @default.
• W4365515710 cites W2012593576 @default.
• W4365515710 cites W2019851585 @default.
• W4365515710 cites W2026745968 @default.
• W4365515710 cites W2035169581 @default.
• W4365515710 cites W2038322646 @default.
• W4365515710 cites W2039105733 @default.
• W4365515710 cites W2042479028 @default.
• W4365515710 cites W2047027281 @default.
• W4365515710 cites W2059548072 @default.
• W4365515710 cites W2060660377 @default.
• W4365515710 cites W2075376185 @default.
• W4365515710 cites W2082047115 @default.
• W4365515710 cites W2093441802 @default.
• W4365515710 cites W2093708030 @default.
• W4365515710 cites W2095554063 @default.
• W4365515710 cites W2096496718 @default.
• W4365515710 cites W2107665951 @default.
• W4365515710 cites W2108868448 @default.
• W4365515710 cites W2111780819 @default.
• W4365515710 cites W2112669742 @default.
• W4365515710 cites W2119076403 @default.
• W4365515710 cites W2119293187 @default.
• W4365515710 cites W2119376399 @default.
• W4365515710 cites W2121888780 @default.
• W4365515710 cites W2122598723 @default.
• W4365515710 cites W2125264382 @default.
• W4365515710 cites W2125326441 @default.
• W4365515710 cites W2127344303 @default.
• W4365515710 cites W2132393729 @default.
• W4365515710 cites W2134678030 @default.
• W4365515710 cites W2135697415 @default.
• W4365515710 cites W2136078012 @default.
• W4365515710 cites W2140784970 @default.
• W4365515710 cites W2142384652 @default.
• W4365515710 cites W2156049957 @default.
• W4365515710 cites W2161633633 @default.
• W4365515710 cites W2162555339 @default.
• W4365515710 cites W2162684905 @default.
• W4365515710 cites W2164027523 @default.
• W4365515710 cites W2165626262 @default.
• W4365515710 cites W2165647350 @default.
• W4365515710 cites W2289977218 @default.
• W4365515710 cites W2307970348 @default.
• W4365515710 cites W2313884214 @default.
• W4365515710 cites W2395533360 @default.
• W4365515710 cites W2473818600 @default.
• W4365515710 cites W2473998234 @default.
• W4365515710 cites W2488623126 @default.
• W4365515710 cites W2554774433 @default.
• W4365515710 cites W2588256621 @default.
• W4365515710 cites W2795086423 @default.
• W4365515710 cites W2798157446 @default.
• W4365515710 cites W2799524357 @default.
• W4365515710 cites W2904084017 @default.
• W4365515710 cites W2955203339 @default.
• W4365515710 cites W2960894757 @default.
• W4365515710 cites W2969271119 @default.
• W4365515710 cites W2975114208 @default.
• W4365515710 cites W2976620503 @default.
• W4365515710 cites W2986984498 @default.
• W4365515710 cites W3009965004 @default.
• W4365515710 cites W3023714422 @default.
• W4365515710 cites W3211795874 @default.
• W4365515710 cites W4285388734 @default.
• W4365515710 cites W4319459323 @default.
• W4365515710 cites W65828984 @default.
• W4365515710 doi "https://doi.org/10.3389/fimmu.2023.1156806" @default.
• W4365515710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37122725" @default.
• W4365515710 hasPublicationYear "2023" @default.
• W4365515710 type Work @default.
• W4365515710 citedByCount "0" @default.
• W4365515710 crossrefType "journal-article" @default.

• next