Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365517283> ?p ?o ?g. }
- W4365517283 endingPage "112377" @default.
- W4365517283 startingPage "112377" @default.
- W4365517283 abstract "The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen deprivation and expression of LY6D. We here demonstrate that conditional deletion of PTEN in the murine prostate epithelium causes an expansion of transformed LY6D+ progenitor cells without impairing stem cell properties. Transcriptomic analyses of LY6D+ luminal cells identified an autocrine positive feedback loop, based on the secretion of amphiregulin (AREG)-mediated activation of mitogen-activated protein kinase (MAPK) signaling, increasing cellular fitness and organoid formation. Pharmacological interference with this pathway overcomes the castration-resistant properties of LY6D+ cells with a suppression of organoid formation and loss of LY6D+ cells in vivo. Notably, LY6D+ tumor cells are enriched in high-grade and androgen-resistant prostate cancer, providing clinical evidence for their contribution to advanced disease. Our data indicate that early interference with MAPK inhibitors can prevent progression of castration-resistant prostate cancer." @default.
- W4365517283 created "2023-04-15" @default.
- W4365517283 creator A5000998549 @default.
- W4365517283 creator A5003396056 @default.
- W4365517283 creator A5013394786 @default.
- W4365517283 creator A5016947205 @default.
- W4365517283 creator A5035568718 @default.
- W4365517283 creator A5041859071 @default.
- W4365517283 creator A5043241243 @default.
- W4365517283 creator A5046453229 @default.
- W4365517283 creator A5050904026 @default.
- W4365517283 creator A5054351395 @default.
- W4365517283 creator A5067775652 @default.
- W4365517283 creator A5077112218 @default.
- W4365517283 creator A5077748162 @default.
- W4365517283 creator A5079490712 @default.
- W4365517283 creator A5087986236 @default.
- W4365517283 creator A5090116229 @default.
- W4365517283 creator A5090864400 @default.
- W4365517283 date "2023-04-01" @default.
- W4365517283 modified "2023-10-18" @default.
- W4365517283 title "Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells" @default.
- W4365517283 cites W1549619413 @default.
- W4365517283 cites W1578291413 @default.
- W4365517283 cites W1580523172 @default.
- W4365517283 cites W1775309324 @default.
- W4365517283 cites W1967698512 @default.
- W4365517283 cites W1970242719 @default.
- W4365517283 cites W1974186507 @default.
- W4365517283 cites W1977679887 @default.
- W4365517283 cites W1985454650 @default.
- W4365517283 cites W1985536810 @default.
- W4365517283 cites W1985827132 @default.
- W4365517283 cites W1989723151 @default.
- W4365517283 cites W1993060180 @default.
- W4365517283 cites W1995612509 @default.
- W4365517283 cites W1997930286 @default.
- W4365517283 cites W2003866931 @default.
- W4365517283 cites W2005274657 @default.
- W4365517283 cites W2007699862 @default.
- W4365517283 cites W2017739035 @default.
- W4365517283 cites W2020276643 @default.
- W4365517283 cites W2022685199 @default.
- W4365517283 cites W2026375113 @default.
- W4365517283 cites W2031263088 @default.
- W4365517283 cites W2032765836 @default.
- W4365517283 cites W2050146329 @default.
- W4365517283 cites W2055149726 @default.
- W4365517283 cites W2064927794 @default.
- W4365517283 cites W2069032457 @default.
- W4365517283 cites W2069264443 @default.
- W4365517283 cites W2069981394 @default.
- W4365517283 cites W2072219853 @default.
- W4365517283 cites W2073100248 @default.
- W4365517283 cites W2078587382 @default.
- W4365517283 cites W2079485476 @default.
- W4365517283 cites W2082161467 @default.
- W4365517283 cites W2100024496 @default.
- W4365517283 cites W2100304447 @default.
- W4365517283 cites W2109373293 @default.
- W4365517283 cites W2109627278 @default.
- W4365517283 cites W2114104545 @default.
- W4365517283 cites W2116102471 @default.
- W4365517283 cites W2119336711 @default.
- W4365517283 cites W2123106337 @default.
- W4365517283 cites W2130410032 @default.
- W4365517283 cites W2131294003 @default.
- W4365517283 cites W2134318982 @default.
- W4365517283 cites W2137750974 @default.
- W4365517283 cites W2144251330 @default.
- W4365517283 cites W2147606689 @default.
- W4365517283 cites W2154189834 @default.
- W4365517283 cites W2154430204 @default.
- W4365517283 cites W2161112598 @default.
- W4365517283 cites W2161865132 @default.
- W4365517283 cites W2162002294 @default.
- W4365517283 cites W2167279371 @default.
- W4365517283 cites W2169456326 @default.
- W4365517283 cites W2180142285 @default.
- W4365517283 cites W2255555283 @default.
- W4365517283 cites W2337738786 @default.
- W4365517283 cites W2529309286 @default.
- W4365517283 cites W2529707188 @default.
- W4365517283 cites W2567987817 @default.
- W4365517283 cites W2581724956 @default.
- W4365517283 cites W2763136348 @default.
- W4365517283 cites W2787640799 @default.
- W4365517283 cites W2788783025 @default.
- W4365517283 cites W2884001931 @default.
- W4365517283 cites W2891940037 @default.
- W4365517283 cites W2905218637 @default.
- W4365517283 cites W2916721669 @default.
- W4365517283 cites W2950114058 @default.
- W4365517283 cites W2952481429 @default.
- W4365517283 cites W2960351153 @default.
- W4365517283 cites W2964315448 @default.
- W4365517283 cites W2966060845 @default.
- W4365517283 cites W2972176863 @default.