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- W4365518616 abstract "Enzalutamide is an eff ective androgen signaling receptor inhibitor that aff ects the androgen pathway in various ways. Enzalutamide can reduce the competitive binding of testosterone to the androgen receptor. It also inhibits the translocation of the activated androgen receptor for the cytoplasm to the nucleus, and its binding to DNA and cofactors recruitment to the binding site. This study evaluated polyvinyl alcohol/chitosan hydrogels as a pH-sensitive matrix drug delivery system for enzalutamide. The release of enzalutamide from PVA/CS hydrogel were determined at the simulated gastric and intestinal fl uid (SGF and SIF, respectively). Various kinetic models were employed to evaluate the drug release’s kinetic mechanism. The drug release was infl uenced by the concentration of polymers, the pH of the release medium, and the amount of cross-linking agent. Hydrogels containing (60:40) PVA to chitosan showed a higher release percentage of about 98% at SIF. The kinetic models showed that the release process follows the Higuchi model in SGF with a regression coeffi cient of 0.925. In contrast, SIF follows the fi rstorder model with a regression coeffi cient value of 0.994. The results confi rmed that the new formed PVA/CS hydrogels are potential systems for enzalutamide-controlled drug delivery" @default.
- W4365518616 created "2023-04-15" @default.
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- W4365518616 date "2023-03-25" @default.
- W4365518616 modified "2023-09-23" @default.
- W4365518616 title "Preparation and Evaluation of PVA, Chitosan Polymeric Matrixes and In-vitro Study for their Controlled Release of Enzalutamide" @default.
- W4365518616 doi "https://doi.org/10.25258/ijddt.13.1.44" @default.
- W4365518616 hasPublicationYear "2023" @default.
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