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- W4365518660 abstract "Background: There is ongoing debate regarding platelet-rich plasma’s (PRP) ability to eff ectively heal soft tissue injuries. Lyophilized platelet-rich plasma (L-PRP) was created and kept using the blood bank’s standard separation procedures. The objective of study was to evaluate eff ects of lyophilization on PRP and its properties such as level of growth factors. Also, the eff ect of storage conditions on growth factors. Methods: The PRPs were created through a two-step centrifugation process and lyophilized. After freeze-thawing to allow platelet growth factors to be released, levels of hepatocyte growth factor (HGF), transforming growth factor (TGF), fi broblast growth factor (FGF)-basic, platelet-derived growth factor (PDGF)-AB, insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) were measured each day during storage. Results: After L-PRP preparation, levels of FGF-basic, VEGF, PDGF-AB, EGF and TGF- beta1 signifi cantly raised and levels of HGF and IGF-1 in L-PRPs had light rise. Conclusions: In comparison to F-PRP, platelet counts and seven growth factors increased during preservation in L-PRP. PRPs that have been stored may be injected several times using our method. L-PRP was effi cacious and stable for 90 days when stored at 8oC." @default.
- W4365518660 created "2023-04-15" @default.
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- W4365518660 date "2023-03-25" @default.
- W4365518660 modified "2023-10-17" @default.
- W4365518660 title "A Comparative Study of Concentration of Growth Factors in Lyophilized PRP with Fresh PRP at Diff erent Storage Conditions" @default.
- W4365518660 doi "https://doi.org/10.25258/ijddt.13.1.27" @default.
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