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W4365794546 abstract "<abstract> <p>Lung adenocarcinoma (LUAD), the most common subtype of lung cancer, is a global health challenge with high recurrence and mortality rates. The coagulation cascade plays an essential role in tumor disease progression and leads to death in LUAD. We differentiated two coagulation-related subtypes in LUAD patients in this study based on coagulation pathways collected from the KEGG database. We then demonstrated significant differences between the two coagulation-associated subtypes regarding immune characteristics and prognostic stratification. For risk stratification and prognostic prediction, we developed a coagulation-related risk score prognostic model in the Cancer Genome Atlas (TCGA) cohort. The GEO cohort also validated the predictive value of the coagulation-related risk score in terms of prognosis and immunotherapy. Based on these results, we identified coagulation-related prognostic factors in LUAD, which may serve as a robust prognostic biomarker for therapeutic and immunotherapeutic efficacy. It may contribute to clinical decision-making in patients with LUAD.</p> </abstract>" @default.
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W4365794546 date "2023-01-01" @default.
W4365794546 modified "2023-10-16" @default.
W4365794546 title "Identification of coagulation-associated subtypes of lung adenocarcinoma and establishment of prognostic models" @default.
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W4365794546 doi "https://doi.org/10.3934/mbe.2023470" @default.
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