Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365794788> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4365794788 endingPage "82" @default.
- W4365794788 startingPage "82" @default.
- W4365794788 abstract "Flavonoids have various pharmacological activities, such as antihypertensive, anticancer, and and antidiabetic effects. Several studies have shown that luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin have antihypertensive effects, but the mechanism of action has yet to be discovered with certainty. This study aims to identify flavonoids from luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin as renin inhibitors through in silico study; seven flavonoid compounds were docked with 2V0Z with renin inhibitor (Aliskiren) in humans (Homo sapiens 6 LU7) using AutoDock v4.2.6. SwissADME was used to evaluate the pharmacokinetic characteristics of these substances. Results molecular binding of luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin, has potential as renin inhibitors with affinity energy values lower than those of aliskiren of -9.3; -9.3; -10.0; -9.2; -9.9; -9.3; and -9.7 kcal/mol. The interactions of these seven compounds have the same catalytic activity as aliskiren on two aspartic acid residues, Asp32 and Asp215. The analysis of pharmacokinetic profiles and the search for physical and chemical properties showed that the seven compounds violated three of the five Lipinski rules, while aliskiren violated one. Hesperitin, kaempferol, and naringenin had similarities with aliskiren on the amino-acid residues in the renin-binding pocket. However, based on pharmacokinetic analysis, the three compounds had an oral pharmacokinetic profile that could have been better than aliskiren." @default.
- W4365794788 created "2023-04-16" @default.
- W4365794788 creator A5017472613 @default.
- W4365794788 creator A5039645694 @default.
- W4365794788 creator A5044990338 @default.
- W4365794788 creator A5063494376 @default.
- W4365794788 creator A5085091477 @default.
- W4365794788 date "2023-01-01" @default.
- W4365794788 modified "2023-10-18" @default.
- W4365794788 title "Investigation renin inhibitor activity from flavonoids derivates by in silico study" @default.
- W4365794788 cites W1278597430 @default.
- W4365794788 cites W1968969590 @default.
- W4365794788 cites W2012946611 @default.
- W4365794788 cites W2145461177 @default.
- W4365794788 cites W2173978055 @default.
- W4365794788 cites W2565383127 @default.
- W4365794788 cites W2593436234 @default.
- W4365794788 cites W2794779247 @default.
- W4365794788 cites W2904419372 @default.
- W4365794788 cites W3048065091 @default.
- W4365794788 cites W3100994999 @default.
- W4365794788 cites W4235412893 @default.
- W4365794788 doi "https://doi.org/10.4103/japtr.japtr_660_22" @default.
- W4365794788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37255870" @default.
- W4365794788 hasPublicationYear "2023" @default.
- W4365794788 type Work @default.
- W4365794788 citedByCount "0" @default.
- W4365794788 crossrefType "journal-article" @default.
- W4365794788 hasAuthorship W4365794788A5017472613 @default.
- W4365794788 hasAuthorship W4365794788A5039645694 @default.
- W4365794788 hasAuthorship W4365794788A5044990338 @default.
- W4365794788 hasAuthorship W4365794788A5063494376 @default.
- W4365794788 hasAuthorship W4365794788A5085091477 @default.
- W4365794788 hasBestOaLocation W43657947881 @default.
- W4365794788 hasConcept C112705442 @default.
- W4365794788 hasConcept C126838900 @default.
- W4365794788 hasConcept C185592680 @default.
- W4365794788 hasConcept C198710026 @default.
- W4365794788 hasConcept C2776080593 @default.
- W4365794788 hasConcept C2776848411 @default.
- W4365794788 hasConcept C2777252647 @default.
- W4365794788 hasConcept C2777810353 @default.
- W4365794788 hasConcept C2778004101 @default.
- W4365794788 hasConcept C2778173338 @default.
- W4365794788 hasConcept C2779054382 @default.
- W4365794788 hasConcept C2779838083 @default.
- W4365794788 hasConcept C2781263971 @default.
- W4365794788 hasConcept C55493867 @default.
- W4365794788 hasConcept C71924100 @default.
- W4365794788 hasConcept C84393581 @default.
- W4365794788 hasConcept C98274493 @default.
- W4365794788 hasConceptScore W4365794788C112705442 @default.
- W4365794788 hasConceptScore W4365794788C126838900 @default.
- W4365794788 hasConceptScore W4365794788C185592680 @default.
- W4365794788 hasConceptScore W4365794788C198710026 @default.
- W4365794788 hasConceptScore W4365794788C2776080593 @default.
- W4365794788 hasConceptScore W4365794788C2776848411 @default.
- W4365794788 hasConceptScore W4365794788C2777252647 @default.
- W4365794788 hasConceptScore W4365794788C2777810353 @default.
- W4365794788 hasConceptScore W4365794788C2778004101 @default.
- W4365794788 hasConceptScore W4365794788C2778173338 @default.
- W4365794788 hasConceptScore W4365794788C2779054382 @default.
- W4365794788 hasConceptScore W4365794788C2779838083 @default.
- W4365794788 hasConceptScore W4365794788C2781263971 @default.
- W4365794788 hasConceptScore W4365794788C55493867 @default.
- W4365794788 hasConceptScore W4365794788C71924100 @default.
- W4365794788 hasConceptScore W4365794788C84393581 @default.
- W4365794788 hasConceptScore W4365794788C98274493 @default.
- W4365794788 hasIssue "2" @default.
- W4365794788 hasLocation W43657947881 @default.
- W4365794788 hasLocation W43657947882 @default.
- W4365794788 hasLocation W43657947883 @default.
- W4365794788 hasOpenAccess W4365794788 @default.
- W4365794788 hasPrimaryLocation W43657947881 @default.
- W4365794788 hasRelatedWork W1967940610 @default.
- W4365794788 hasRelatedWork W2001427334 @default.
- W4365794788 hasRelatedWork W2027155648 @default.
- W4365794788 hasRelatedWork W2154634938 @default.
- W4365794788 hasRelatedWork W2349436834 @default.
- W4365794788 hasRelatedWork W2383832551 @default.
- W4365794788 hasRelatedWork W3210051376 @default.
- W4365794788 hasRelatedWork W4365794788 @default.
- W4365794788 hasRelatedWork W748692431 @default.
- W4365794788 hasRelatedWork W2487797362 @default.
- W4365794788 hasVolume "14" @default.
- W4365794788 isParatext "false" @default.
- W4365794788 isRetracted "false" @default.
- W4365794788 workType "article" @default.