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- W4365810921 endingPage "233" @default.
- W4365810921 startingPage "225" @default.
- W4365810921 abstract "Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct type of primary brain tumors with unique characteristics, behavior, and disease outcomes. This article provides a review of standard of care treatment options and innovative, therapeutic approaches that are currently under investigation for these tumors.Extensive pre-clinical data and a variety of clinical studies support targeting IDH mutations in glioma using different mechanisms, which include direct inhibition and immunotherapies that target metabolic and epigenomic vulnerabilities caused by these mutations. IDH mutations have been recognized as an oncogenic driver in gliomas for more than a decade and as a positive prognostic factor influencing the research for new therapeutic methods including IDH inhibitors, DNA repair inhibitors, and immunotherapy." @default.
- W4365810921 created "2023-04-16" @default.
- W4365810921 creator A5044660518 @default.
- W4365810921 creator A5080040856 @default.
- W4365810921 date "2023-04-15" @default.
- W4365810921 modified "2023-10-01" @default.
- W4365810921 title "Therapies for IDH-Mutant Gliomas" @default.
- W4365810921 cites W1624957772 @default.
- W4365810921 cites W1695525132 @default.
- W4365810921 cites W1834978976 @default.
- W4365810921 cites W1887038943 @default.
- W4365810921 cites W1893588436 @default.
- W4365810921 cites W1904199299 @default.
- W4365810921 cites W1971463695 @default.
- W4365810921 cites W1978092831 @default.
- W4365810921 cites W1993605227 @default.
- W4365810921 cites W2002134084 @default.
- W4365810921 cites W2010573862 @default.
- W4365810921 cites W2013020286 @default.
- W4365810921 cites W2036044314 @default.
- W4365810921 cites W203981073 @default.
- W4365810921 cites W2040827479 @default.
- W4365810921 cites W2047867594 @default.
- W4365810921 cites W2055475004 @default.
- W4365810921 cites W2056895881 @default.
- W4365810921 cites W2059051635 @default.
- W4365810921 cites W2069059931 @default.
- W4365810921 cites W2088293916 @default.
- W4365810921 cites W2088631065 @default.
- W4365810921 cites W2098341282 @default.
- W4365810921 cites W2106649727 @default.
- W4365810921 cites W2110102835 @default.
- W4365810921 cites W2110128697 @default.
- W4365810921 cites W2112495947 @default.
- W4365810921 cites W2118286342 @default.
- W4365810921 cites W2119838967 @default.
- W4365810921 cites W2126665584 @default.
- W4365810921 cites W2126817554 @default.
- W4365810921 cites W2128883307 @default.
- W4365810921 cites W2133865472 @default.
- W4365810921 cites W2134942438 @default.
- W4365810921 cites W2144727376 @default.
- W4365810921 cites W2147013683 @default.
- W4365810921 cites W2148977460 @default.
- W4365810921 cites W2150929170 @default.
- W4365810921 cites W2158900087 @default.
- W4365810921 cites W2159842626 @default.
- W4365810921 cites W2160382843 @default.
- W4365810921 cites W2163440976 @default.
- W4365810921 cites W2164277652 @default.
- W4365810921 cites W2165307233 @default.
- W4365810921 cites W2167560492 @default.
- W4365810921 cites W2171212160 @default.
- W4365810921 cites W2183991412 @default.
- W4365810921 cites W2186262563 @default.
- W4365810921 cites W2222531233 @default.
- W4365810921 cites W2240994600 @default.
- W4365810921 cites W2293496672 @default.
- W4365810921 cites W2366536035 @default.
- W4365810921 cites W2428936938 @default.
- W4365810921 cites W2475161005 @default.
- W4365810921 cites W2496785181 @default.
- W4365810921 cites W2556519788 @default.
- W4365810921 cites W2562161487 @default.
- W4365810921 cites W2585230893 @default.
- W4365810921 cites W2588147230 @default.
- W4365810921 cites W2592842961 @default.
- W4365810921 cites W2596261790 @default.
- W4365810921 cites W2599575490 @default.
- W4365810921 cites W2610522657 @default.
- W4365810921 cites W2659205250 @default.
- W4365810921 cites W2744160381 @default.
- W4365810921 cites W2750745141 @default.
- W4365810921 cites W2767664052 @default.
- W4365810921 cites W2770032077 @default.
- W4365810921 cites W2785262117 @default.
- W4365810921 cites W2795704001 @default.
- W4365810921 cites W2797889616 @default.
- W4365810921 cites W2878436114 @default.
- W4365810921 cites W2884335666 @default.
- W4365810921 cites W2884741638 @default.
- W4365810921 cites W2885452842 @default.
- W4365810921 cites W2890389550 @default.
- W4365810921 cites W2891414792 @default.
- W4365810921 cites W2896027205 @default.
- W4365810921 cites W2946499155 @default.
- W4365810921 cites W3002811127 @default.
- W4365810921 cites W3015988344 @default.
- W4365810921 cites W3019769209 @default.
- W4365810921 cites W3034266209 @default.
- W4365810921 cites W3043701315 @default.
- W4365810921 cites W3111384264 @default.
- W4365810921 cites W3129761482 @default.
- W4365810921 cites W3149683966 @default.
- W4365810921 cites W3161800158 @default.
- W4365810921 cites W3164133956 @default.
- W4365810921 cites W3169360454 @default.
- W4365810921 cites W3174246647 @default.