Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365811085> ?p ?o ?g. }
- W4365811085 abstract "Microglia are dynamic resident immune cells of the central nervous system (CNS) that sense, survey, and respond to changes in their environment. In disease states, microglia transform from homeostatic to diverse molecular phenotypic states that play complex and causal roles in neurologic disease pathogenesis, as evidenced by the identification of microglial genes as genetic risk factors for neurodegenerative disease. While advances in transcriptomic profiling of microglia from the CNS of humans and animal models have provided transformative insights, the transcriptome is only modestly reflective of the proteome. Proteomic profiling of microglia is therefore more likely to provide functionally and therapeutically relevant targets. In this review, we discuss molecular insights gained from transcriptomic studies of microglia in the context of Alzheimer's disease as a prototypic neurodegenerative disease, and highlight existing and emerging approaches for proteomic profiling of microglia derived from in vivo model systems and human brain." @default.
- W4365811085 created "2023-04-16" @default.
- W4365811085 creator A5014749047 @default.
- W4365811085 creator A5015899772 @default.
- W4365811085 creator A5022426223 @default.
- W4365811085 creator A5031361476 @default.
- W4365811085 creator A5053212606 @default.
- W4365811085 creator A5073279323 @default.
- W4365811085 date "2023-05-02" @default.
- W4365811085 modified "2023-10-14" @default.
- W4365811085 title "Advances in proteomic phenotyping of microglia in neurodegeneration" @default.
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