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• W4365811204 abstract "Polyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segments on PAA prevent the electrostatic repulsion among the ionized carboxyl groups and absorbed TA to form coacervates. The absorbed TA provides solid adhesion to dry and wet substrates via multifarious interactions, which endows the coacervate with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. This coacervate achieves desirable self-healing and extensible properties suitable for frequently moving joints. These investigations prove that the coacervate has strong antibacterial activity, facilitates fibroblast migration, and modulates M1/M2 polarization of macrophages. In vivo hemorrhage experiments further confirm that the coacervate dramatically shortens the hemostatic time from hundreds to tens of seconds. In addition, full-thickness skin defect experiments demonstrate that the coacervate achieves the best therapeutic effect by significantly promoting collagen deposition, angiogenesis, and epithelialization. These results demonstrate that a PAA-based coacervate hydrogel is a promising wound dressing for medical translation." @default.
• W4365811204 created "2023-04-16" @default.
• W4365811204 creator A5010779399 @default.
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• W4365811204 date "2023-04-14" @default.
• W4365811204 modified "2023-10-14" @default.
• W4365811204 title "Bioinspired Polyacrylic Acid‐Based Dressing: Wet Adhesive, Self‐Healing, and Multi‐Biofunctional Coacervate Hydrogel Accelerates Wound Healing" @default.
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• W4365811204 doi "https://doi.org/10.1002/advs.202207352" @default.
• W4365811204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37060151" @default.
• W4365811204 hasPublicationYear "2023" @default.
• W4365811204 type Work @default.
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