FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366000371> ?p ?o ?g. }

• W4366000371 endingPage "102724" @default.
• W4366000371 startingPage "102724" @default.
• W4366000371 abstract "The placenta-specific 8 (PLAC8) gene, also known as ONZIN or C15, codes for a cysteine-rich peptide originally identified in mouse placental tissue and subsequently identified in a variety of epithelial tissues and immune cells. PLAC8 is also expressed in birds, such as ducks, where its functional roles remain unknown. Here, we aimed to determine the mRNA and protein expression profiles and the functional role of duck PLAC8 during the infection of duck hepatitis A virus type 1 (DHAV-1). We found that the duck PLAC8 is also a cysteine-rich polypeptide composed of 114 amino acid residues, with no signal peptide. Duck PLAC8 is highly expressed in the immune organs of young cherry valley ducks, including the thymus, bursa fabricius, and spleen. However, it has negligible expression level in liver, brain, kidney, and heart. Additionally, PLAC8 expression was considerably induced after DHAV-1 infection both in vitro and in vivo, especially in the immune organs of ducklings. This tissue expression distribution and induction upon infection suggest that PLAC8 might play a critical role in innate immunity. Our data showed that PLAC8 significantly suppressed the expression of Toll-like receptor 7 (TLR7), leading to decreased expression of downstream signaling molecules including myeloid differentiation primary response gene 88 (MyD88) and nuclear factor kappa-B (NF-κB). This ultimately resulted in low levels of type I interferon and interleukin 6 (IL-6). Additionally, PLAC8 positively regulated DHAV-1 replication levels. RNAi against PLAC8 in duck embryo fibroblasts considerably inhibited DHAV-1 propagation, while PLAC8 overexpression significantly facilitated DHAV-1 replication." @default.
• W4366000371 created "2023-04-17" @default.
• W4366000371 creator A5006131292 @default.
• W4366000371 creator A5009420503 @default.
• W4366000371 creator A5032619855 @default.
• W4366000371 creator A5066550564 @default.
• W4366000371 creator A5080674896 @default.
• W4366000371 creator A5083358220 @default.
• W4366000371 date "2023-07-01" @default.
• W4366000371 modified "2023-09-26" @default.
• W4366000371 title "Placenta-specific 8 facilitates the infection of duck hepatitis A virus type 1 by inhibiting the TLR7 MyD88-dependent signaling pathway" @default.
• W4366000371 cites W1536955403 @default.
• W4366000371 cites W1965322287 @default.
• W4366000371 cites W1969072247 @default.
• W4366000371 cites W1969430178 @default.
• W4366000371 cites W1972776583 @default.
• W4366000371 cites W1992967332 @default.
• W4366000371 cites W1994391392 @default.
• W4366000371 cites W1994942139 @default.
• W4366000371 cites W2011678998 @default.
• W4366000371 cites W2015475607 @default.
• W4366000371 cites W2052046406 @default.
• W4366000371 cites W2055797427 @default.
• W4366000371 cites W2066728093 @default.
• W4366000371 cites W2076109805 @default.
• W4366000371 cites W2091978007 @default.
• W4366000371 cites W2115224817 @default.
• W4366000371 cites W2117691023 @default.
• W4366000371 cites W2148499789 @default.
• W4366000371 cites W2161208630 @default.
• W4366000371 cites W2195240341 @default.
• W4366000371 cites W2749569093 @default.
• W4366000371 cites W2807287045 @default.
• W4366000371 cites W2809383935 @default.
• W4366000371 cites W2951205992 @default.
• W4366000371 cites W2994280642 @default.
• W4366000371 cites W3007409430 @default.
• W4366000371 cites W3041245012 @default.
• W4366000371 cites W3202150267 @default.
• W4366000371 cites W4225107700 @default.
• W4366000371 cites W4235029171 @default.
• W4366000371 doi "https://doi.org/10.1016/j.psj.2023.102724" @default.
• W4366000371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37207573" @default.
• W4366000371 hasPublicationYear "2023" @default.
• W4366000371 type Work @default.
• W4366000371 citedByCount "0" @default.
• W4366000371 crossrefType "journal-article" @default.
• W4366000371 hasAuthorship W4366000371A5006131292 @default.
• W4366000371 hasAuthorship W4366000371A5009420503 @default.
• W4366000371 hasAuthorship W4366000371A5032619855 @default.
• W4366000371 hasAuthorship W4366000371A5066550564 @default.
• W4366000371 hasAuthorship W4366000371A5080674896 @default.
• W4366000371 hasAuthorship W4366000371A5083358220 @default.
• W4366000371 hasBestOaLocation W43660003711 @default.
• W4366000371 hasConcept C104317684 @default.
• W4366000371 hasConcept C136449434 @default.
• W4366000371 hasConcept C159047783 @default.
• W4366000371 hasConcept C166703698 @default.
• W4366000371 hasConcept C170493617 @default.
• W4366000371 hasConcept C203014093 @default.
• W4366000371 hasConcept C2776709828 @default.
• W4366000371 hasConcept C2779836521 @default.
• W4366000371 hasConcept C2780931953 @default.
• W4366000371 hasConcept C54355233 @default.
• W4366000371 hasConcept C62478195 @default.
• W4366000371 hasConcept C67705224 @default.
• W4366000371 hasConcept C86803240 @default.
• W4366000371 hasConcept C8891405 @default.
• W4366000371 hasConcept C95444343 @default.
• W4366000371 hasConceptScore W4366000371C104317684 @default.
• W4366000371 hasConceptScore W4366000371C136449434 @default.
• W4366000371 hasConceptScore W4366000371C159047783 @default.
• W4366000371 hasConceptScore W4366000371C166703698 @default.
• W4366000371 hasConceptScore W4366000371C170493617 @default.
• W4366000371 hasConceptScore W4366000371C203014093 @default.
• W4366000371 hasConceptScore W4366000371C2776709828 @default.
• W4366000371 hasConceptScore W4366000371C2779836521 @default.
• W4366000371 hasConceptScore W4366000371C2780931953 @default.
• W4366000371 hasConceptScore W4366000371C54355233 @default.
• W4366000371 hasConceptScore W4366000371C62478195 @default.
• W4366000371 hasConceptScore W4366000371C67705224 @default.
• W4366000371 hasConceptScore W4366000371C86803240 @default.
• W4366000371 hasConceptScore W4366000371C8891405 @default.
• W4366000371 hasConceptScore W4366000371C95444343 @default.
• W4366000371 hasIssue "7" @default.
• W4366000371 hasLocation W43660003711 @default.
• W4366000371 hasLocation W43660003712 @default.
• W4366000371 hasLocation W43660003713 @default.
• W4366000371 hasOpenAccess W4366000371 @default.
• W4366000371 hasPrimaryLocation W43660003711 @default.
• W4366000371 hasRelatedWork W140295565 @default.
• W4366000371 hasRelatedWork W2029433700 @default.
• W4366000371 hasRelatedWork W2081358646 @default.
• W4366000371 hasRelatedWork W2141330728 @default.
• W4366000371 hasRelatedWork W2165321096 @default.
• W4366000371 hasRelatedWork W2894391419 @default.
• W4366000371 hasRelatedWork W2902358729 @default.
• W4366000371 hasRelatedWork W4233477515 @default.

• next