FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366000596> ?p ?o ?g. }

• W4366000596 endingPage "562" @default.
• W4366000596 startingPage "553" @default.
• W4366000596 abstract "Precise combination therapy, involving multiple chemotherapeutics with pharmacologically synergistic antitumor effects, is a promising approach to address the challenge of monotherapy with insufficient activity towards their targets of interest. We employed Pt←pyridine coordination-driven assembly to construct a stoichiometric coordination complex of camptothecin and organoplatinum (II) (Pt-CPT). The Pt-CPT complex exhibited a remarkable synergistic effect toward several tumor cell lines, which is equal to the optimal synergistic effect of (PEt3)2Pt(OTf)2 (Pt) and CPT mixture at various ratios. An amphiphilic polymer with H2O2-responsiveness and glutathione (GSH)-depleting ability (PO) was used to encapsulate Pt-CPT complex to enable the nanomedicine (Pt-CPT@PO) with prolonged blood circulation and elevated tumor accumulation. The Pt-CPT@PO nanomedicine exhibited remarkable synergistic antitumor efficacy and antimetastatic effect on a mice orthotopic breast tumor model. This work demonstrated the potential of stoichiometric coordination-driven assembly of organic therapeutics with metal-based drugs in developing advanced nanomedicine with optimal synergistic antitumor activity. STATEMENT OF SIGNIFICANCE: In this study, for the first time, we employed Pt←pyridine coordination-driven assembly to construct a stoichiometric coordination complex of camptothecin and organoplatinum (II) (Pt-CPT), with an optimal synergistic effect at various ratios. Then it was encapsulated into an amphiphilic polymer with H2O2-responsiveness and glutathione (GSH)-depleting ability (PO) to enable the nanomedicine (Pt-CPT@PO) with prolonged blood circulation and elevated tumor accumulation. The Pt-CPT@PO nanomedicine exhibited remarkable synergistic antitumor efficacy and antimetastatic effect on a mice orthotopic breast tumor model." @default.
• W4366000596 created "2023-04-17" @default.
• W4366000596 creator A5000810051 @default.
• W4366000596 creator A5003281764 @default.
• W4366000596 creator A5003341785 @default.
• W4366000596 creator A5003753200 @default.
• W4366000596 creator A5006822602 @default.
• W4366000596 creator A5029360035 @default.
• W4366000596 creator A5039348177 @default.
• W4366000596 creator A5039877178 @default.
• W4366000596 creator A5042030558 @default.
• W4366000596 creator A5052676364 @default.
• W4366000596 creator A5075889094 @default.
• W4366000596 date "2023-07-01" @default.
• W4366000596 modified "2023-09-29" @default.
• W4366000596 title "A nanomedicine based on stoichiometric coordination of camptothecin and organoplatinum (II) for synergistic antitumor therapy" @default.
• W4366000596 cites W1496626589 @default.
• W4366000596 cites W1562326085 @default.
• W4366000596 cites W2017681697 @default.
• W4366000596 cites W2028292209 @default.
• W4366000596 cites W2033271093 @default.
• W4366000596 cites W2073683299 @default.
• W4366000596 cites W2077903176 @default.
• W4366000596 cites W2079803577 @default.
• W4366000596 cites W2088223764 @default.
• W4366000596 cites W2128906171 @default.
• W4366000596 cites W2129174532 @default.
• W4366000596 cites W2130177169 @default.
• W4366000596 cites W2143463421 @default.
• W4366000596 cites W2146274229 @default.
• W4366000596 cites W2162994503 @default.
• W4366000596 cites W2282989227 @default.
• W4366000596 cites W2283420536 @default.
• W4366000596 cites W2319491830 @default.
• W4366000596 cites W2328082795 @default.
• W4366000596 cites W2518509288 @default.
• W4366000596 cites W2554773181 @default.
• W4366000596 cites W2590680367 @default.
• W4366000596 cites W2607402714 @default.
• W4366000596 cites W2763124849 @default.
• W4366000596 cites W2782330970 @default.
• W4366000596 cites W2801859531 @default.
• W4366000596 cites W2808212266 @default.
• W4366000596 cites W2896706456 @default.
• W4366000596 cites W2913231661 @default.
• W4366000596 cites W2913880753 @default.
• W4366000596 cites W2919219118 @default.
• W4366000596 cites W2925016309 @default.
• W4366000596 cites W2937766145 @default.
• W4366000596 cites W2976048783 @default.
• W4366000596 cites W3001825355 @default.
• W4366000596 cites W3004169989 @default.
• W4366000596 cites W3007144714 @default.
• W4366000596 cites W3024446981 @default.
• W4366000596 cites W3044132586 @default.
• W4366000596 cites W3085879689 @default.
• W4366000596 cites W3096521890 @default.
• W4366000596 cites W3098521917 @default.
• W4366000596 cites W3110067507 @default.
• W4366000596 cites W3111454367 @default.
• W4366000596 cites W3118070495 @default.
• W4366000596 cites W3118423774 @default.
• W4366000596 cites W3133735884 @default.
• W4366000596 cites W3150675584 @default.
• W4366000596 cites W3165400544 @default.
• W4366000596 cites W3216163711 @default.
• W4366000596 cites W4210853074 @default.
• W4366000596 cites W4211214747 @default.
• W4366000596 cites W4214679454 @default.
• W4366000596 cites W4283272474 @default.
• W4366000596 cites W4283363656 @default.
• W4366000596 cites W4285587098 @default.
• W4366000596 cites W4295747765 @default.
• W4366000596 doi "https://doi.org/10.1016/j.actbio.2023.04.010" @default.
• W4366000596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37072068" @default.
• W4366000596 hasPublicationYear "2023" @default.
• W4366000596 type Work @default.
• W4366000596 citedByCount "0" @default.
• W4366000596 crossrefType "journal-article" @default.
• W4366000596 hasAuthorship W4366000596A5000810051 @default.
• W4366000596 hasAuthorship W4366000596A5003281764 @default.
• W4366000596 hasAuthorship W4366000596A5003341785 @default.
• W4366000596 hasAuthorship W4366000596A5003753200 @default.
• W4366000596 hasAuthorship W4366000596A5006822602 @default.
• W4366000596 hasAuthorship W4366000596A5029360035 @default.
• W4366000596 hasAuthorship W4366000596A5039348177 @default.
• W4366000596 hasAuthorship W4366000596A5039877178 @default.
• W4366000596 hasAuthorship W4366000596A5042030558 @default.
• W4366000596 hasAuthorship W4366000596A5052676364 @default.
• W4366000596 hasAuthorship W4366000596A5075889094 @default.
• W4366000596 hasConcept C15083742 @default.
• W4366000596 hasConcept C155672457 @default.
• W4366000596 hasConcept C15920480 @default.
• W4366000596 hasConcept C171250308 @default.
• W4366000596 hasConcept C178790620 @default.
• W4366000596 hasConcept C181199279 @default.
• W4366000596 hasConcept C185592680 @default.
• W4366000596 hasConcept C192562407 @default.

• next