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- W4366001296 endingPage "102305" @default.
- W4366001296 startingPage "102305" @default.
- W4366001296 abstract "The discovery of functional protein complex and the interrogation of the complex structure-function relationship (SFR) play crucial roles in the understanding and intervention of biological processes. Affinity purification-mass spectrometry (AP-MS) has been proved as a powerful tool in the discovery of protein complexes. However, validation of these novel protein complexes as well as elucidation of their molecular interaction mechanisms are still challenging. Recently, native top-down MS (nTDMS) is rapidly developed for the structural analysis of protein complexes. In this review, we discuss the integration of AP-MS and nTDMS in the discovery and structural characterization of functional protein complexes. Further, we think the emerging artificial intelligence (AI)-based protein structure prediction is highly complementary to nTDMS and can promote each other. We expect the hybridization of integrated structural MS with AI prediction to be a powerful workflow in the discovery and SFR investigation of functional protein complexes." @default.
- W4366001296 created "2023-04-17" @default.
- W4366001296 creator A5004366299 @default.
- W4366001296 creator A5022157934 @default.
- W4366001296 creator A5024691353 @default.
- W4366001296 creator A5069877503 @default.
- W4366001296 creator A5084134658 @default.
- W4366001296 date "2023-06-01" @default.
- W4366001296 modified "2023-09-30" @default.
- W4366001296 title "Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization" @default.
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