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• W4366003313 abstract "Abstract Biophysically detailed simulations attempting to reproduce neuronal activity often rely on solving large systems of differential equations; in some models, these systems have tens of thousands of states per cell. Numerically solving these equations is computationally intensive and requires making assumptions about the initial cell states. Additional realism from incorporating more biological detail is achieved at the cost of increasingly more states, more computational resources, and more modeling assumptions. We show that for both point and morphologically-detailed cell models, the presence and timing of future action potentials is probabilistically well-characterized by the relative timings of a small number of recent synaptic events alone. Knowledge of initial conditions or full synaptic input history is not a requirement. While model time constants, etc. impact the specifics, we demonstrate that for both individual spikes and sustained cellular activity, the uncertainty in spike response decreases to the point of approximate determinism. Further, we show cellular model states are reconstructable from ongoing synaptic events, despite unknown initial conditions. We propose that a strictly event-based modeling framework is capable of representing the full complexity of cellular dynamics of the differential-equations models with significantly less per-cell state variables, thus offering a pathway toward utilizing modern data-driven modeling to scale up to larger network models while preserving individual cellular biophysics." @default.
• W4366003313 created "2023-04-17" @default.
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• W4366003313 date "2023-04-16" @default.
• W4366003313 modified "2023-10-13" @default.
• W4366003313 title "Reproducibility of biophysical<i>in silico</i>neuron states and spikes from event-based partial histories" @default.
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• W4366003313 doi "https://doi.org/10.1101/2023.04.15.536945" @default.
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