FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366076639> ?p ?o ?g. }

• W4366076639 abstract "Cardiovascular disease (CVD) remains the major cause of excess mortality in patients with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the individual contribution of NAFLD to CVD risk factors in the absence of pathogenic influences from other comorbidities often found in NAFLD patients, by using an established in-vitro model of hepatic steatosis. Histopathological events in non-alcoholic fatty liver disease were recapitulated by focused metabolic nutrient overload of hepatoblastoma C3A cells, using oleate-treated-cells and untreated controls for comparison. Microarray and proteomic data from cell culture experiments were integrated into a custom-built systems biology database and proteogenomics analysis performed. Candidate genes with significant dysregulation and concomitant changes in protein abundance were identified and STRING association and enrichment analysis performed to identify putative pathogenic pathways. The search strategy yielded 3 candidate genes that were specifically and significantly up-regulated in nutrient-overloaded cells compared to untreated controls: fibrinogen alpha chain (2.2 fold), fibrinogen beta chain (2.3 fold) and fibrinogen gamma chain (2.1 fold) (all rank products pfp <0.05). Fibrinogen alpha and gamma chain also demonstrated significant concomitant increases in protein abundance (3.8-fold and 2.0-fold, respectively, p <0.05). In-vitro modelling of NAFLD and reactive oxygen species formation in nutrient overloaded C3A cells, in the absence of pathogenic influences from other comorbidities, suggests that NAFLD is an isolated determinant of CVD. Nutrient overload-induced up-regulation of all three fibrinogen component subunits of the coagulation cascade provides a possible mechanism to explain the excess CVD mortality observed in NAFLD patients." @default.
• W4366076639 created "2023-04-19" @default.
• W4366076639 creator A5010858937 @default.
• W4366076639 creator A5016442507 @default.
• W4366076639 creator A5021323494 @default.
• W4366076639 creator A5032205819 @default.
• W4366076639 creator A5033253312 @default.
• W4366076639 creator A5036256051 @default.
• W4366076639 creator A5037079497 @default.
• W4366076639 creator A5039092123 @default.
• W4366076639 creator A5052890942 @default.
• W4366076639 creator A5068122614 @default.
• W4366076639 creator A5080719772 @default.
• W4366076639 creator A5088618017 @default.
• W4366076639 date "2015-08-10" @default.
• W4366076639 modified "2023-10-02" @default.
• W4366076639 title "Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events?" @default.
• W4366076639 cites W1602144231 @default.
• W4366076639 cites W1963886173 @default.
• W4366076639 cites W1968384054 @default.
• W4366076639 cites W1969295126 @default.
• W4366076639 cites W1981093360 @default.
• W4366076639 cites W1986656413 @default.
• W4366076639 cites W1987474460 @default.
• W4366076639 cites W1987923280 @default.
• W4366076639 cites W1999950621 @default.
• W4366076639 cites W2001837599 @default.
• W4366076639 cites W2012957079 @default.
• W4366076639 cites W2013446239 @default.
• W4366076639 cites W2021470166 @default.
• W4366076639 cites W2034619043 @default.
• W4366076639 cites W2038963685 @default.
• W4366076639 cites W2074466892 @default.
• W4366076639 cites W2081098333 @default.
• W4366076639 cites W2082299591 @default.
• W4366076639 cites W2098555833 @default.
• W4366076639 cites W2107115075 @default.
• W4366076639 cites W2110065044 @default.
• W4366076639 cites W2111490331 @default.
• W4366076639 cites W2123216266 @default.
• W4366076639 cites W2126622767 @default.
• W4366076639 cites W2131113030 @default.
• W4366076639 cites W2145971342 @default.
• W4366076639 cites W2148562253 @default.
• W4366076639 cites W2149240150 @default.
• W4366076639 cites W2160697532 @default.
• W4366076639 cites W2162746476 @default.
• W4366076639 cites W2469015443 @default.
• W4366076639 cites W4210956151 @default.
• W4366076639 cites W4243395449 @default.
• W4366076639 cites W66838982 @default.
• W4366076639 cites W2072686864 @default.
• W4366076639 doi "https://doi.org/10.1186/s12944-015-0069-3" @default.
• W4366076639 hasPublicationYear "2015" @default.
• W4366076639 type Work @default.
• W4366076639 citedByCount "12" @default.
• W4366076639 countsByYear W43660766392016 @default.
• W4366076639 countsByYear W43660766392017 @default.
• W4366076639 countsByYear W43660766392018 @default.
• W4366076639 countsByYear W43660766392020 @default.
• W4366076639 countsByYear W43660766392021 @default.
• W4366076639 countsByYear W43660766392022 @default.
• W4366076639 crossrefType "journal-article" @default.
• W4366076639 hasAuthorship W4366076639A5010858937 @default.
• W4366076639 hasAuthorship W4366076639A5016442507 @default.
• W4366076639 hasAuthorship W4366076639A5021323494 @default.
• W4366076639 hasAuthorship W4366076639A5032205819 @default.
• W4366076639 hasAuthorship W4366076639A5033253312 @default.
• W4366076639 hasAuthorship W4366076639A5036256051 @default.
• W4366076639 hasAuthorship W4366076639A5037079497 @default.
• W4366076639 hasAuthorship W4366076639A5039092123 @default.
• W4366076639 hasAuthorship W4366076639A5052890942 @default.
• W4366076639 hasAuthorship W4366076639A5068122614 @default.
• W4366076639 hasAuthorship W4366076639A5080719772 @default.
• W4366076639 hasAuthorship W4366076639A5088618017 @default.
• W4366076639 hasBestOaLocation W43660766391 @default.
• W4366076639 hasConcept C126322002 @default.
• W4366076639 hasConcept C134018914 @default.
• W4366076639 hasConcept C2776175330 @default.
• W4366076639 hasConcept C2778772119 @default.
• W4366076639 hasConcept C2779036427 @default.
• W4366076639 hasConcept C2779134260 @default.
• W4366076639 hasConcept C55493867 @default.
• W4366076639 hasConcept C71924100 @default.
• W4366076639 hasConcept C86803240 @default.
• W4366076639 hasConceptScore W4366076639C126322002 @default.
• W4366076639 hasConceptScore W4366076639C134018914 @default.
• W4366076639 hasConceptScore W4366076639C2776175330 @default.
• W4366076639 hasConceptScore W4366076639C2778772119 @default.
• W4366076639 hasConceptScore W4366076639C2779036427 @default.
• W4366076639 hasConceptScore W4366076639C2779134260 @default.
• W4366076639 hasConceptScore W4366076639C55493867 @default.
• W4366076639 hasConceptScore W4366076639C71924100 @default.
• W4366076639 hasConceptScore W4366076639C86803240 @default.
• W4366076639 hasIssue "1" @default.
• W4366076639 hasLocation W43660766391 @default.
• W4366076639 hasLocation W43660766392 @default.
• W4366076639 hasLocation W43660766393 @default.
• W4366076639 hasLocation W43660766394 @default.
• W4366076639 hasOpenAccess W4366076639 @default.

• next