Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366076694> ?p ?o ?g. }
- W4366076694 endingPage "13686" @default.
- W4366076694 startingPage "13683" @default.
- W4366076694 abstract "Detecting small sequences of RNA in biological samples such as microRNA or viral RNA demands highly sensitive and specific methods. Here, a reconfigurable DNA origami template has been used where a chiral arrangement of gold nanorods on the structure can lead to the generation of strong circular dichroism (CD). Switching of the cross-like DNA structure is achieved by the addition of nucleic acid sequences, which arrests the structure in one of the possible chiral states by specific molecular recognition. A specific sequence can thus be detected through the resulting changes in the plasmonic CD spectrum. We show the sensitive and selective detection of a target RNA sequence from the hepatitis C virus genome. The RNA binds to a complementary sequence that is part of the lock mechanism, which leads to the formation of a defined state of the plasmonic system with a distinct optical response. With this approach, we were able to detect this specific RNA sequence at concentrations as low as 100 pm." @default.
- W4366076694 created "2023-04-19" @default.
- W4366076694 creator A5024329973 @default.
- W4366076694 creator A5046044920 @default.
- W4366076694 creator A5065609760 @default.
- W4366076694 creator A5090997817 @default.
- W4366076694 date "2018-09-19" @default.
- W4366076694 modified "2023-10-14" @default.
- W4366076694 title "Sensing Picomolar Concentrations of RNA Using Switchable Plasmonic Chirality" @default.
- W4366076694 cites W1589374402 @default.
- W4366076694 cites W1617520624 @default.
- W4366076694 cites W1964250581 @default.
- W4366076694 cites W1964535590 @default.
- W4366076694 cites W1967710255 @default.
- W4366076694 cites W1973714168 @default.
- W4366076694 cites W1975679096 @default.
- W4366076694 cites W1976815031 @default.
- W4366076694 cites W1979232921 @default.
- W4366076694 cites W1979238706 @default.
- W4366076694 cites W1982810690 @default.
- W4366076694 cites W1984339041 @default.
- W4366076694 cites W2005615084 @default.
- W4366076694 cites W2008590513 @default.
- W4366076694 cites W2014727170 @default.
- W4366076694 cites W2018196842 @default.
- W4366076694 cites W2021784855 @default.
- W4366076694 cites W2024436067 @default.
- W4366076694 cites W2034758576 @default.
- W4366076694 cites W2042924251 @default.
- W4366076694 cites W2048134161 @default.
- W4366076694 cites W2049721533 @default.
- W4366076694 cites W2050993261 @default.
- W4366076694 cites W2055079936 @default.
- W4366076694 cites W2055155291 @default.
- W4366076694 cites W2056483398 @default.
- W4366076694 cites W2057800132 @default.
- W4366076694 cites W2071666523 @default.
- W4366076694 cites W2071829817 @default.
- W4366076694 cites W2079928341 @default.
- W4366076694 cites W2080396763 @default.
- W4366076694 cites W2088084709 @default.
- W4366076694 cites W2100473511 @default.
- W4366076694 cites W2103409481 @default.
- W4366076694 cites W2113749363 @default.
- W4366076694 cites W2126961173 @default.
- W4366076694 cites W2127333628 @default.
- W4366076694 cites W2129096474 @default.
- W4366076694 cites W2130906772 @default.
- W4366076694 cites W2138054293 @default.
- W4366076694 cites W2297980443 @default.
- W4366076694 cites W2305844627 @default.
- W4366076694 cites W2307507937 @default.
- W4366076694 cites W2322870111 @default.
- W4366076694 cites W2325033987 @default.
- W4366076694 cites W2327048176 @default.
- W4366076694 cites W2329663058 @default.
- W4366076694 cites W2330636887 @default.
- W4366076694 cites W2346361489 @default.
- W4366076694 cites W2401438934 @default.
- W4366076694 cites W2510231315 @default.
- W4366076694 cites W2594402484 @default.
- W4366076694 cites W2601435761 @default.
- W4366076694 cites W2605555202 @default.
- W4366076694 cites W2607169985 @default.
- W4366076694 cites W2609836588 @default.
- W4366076694 cites W2738216624 @default.
- W4366076694 cites W2754553126 @default.
- W4366076694 cites W2756006813 @default.
- W4366076694 cites W2760505977 @default.
- W4366076694 cites W2768043621 @default.
- W4366076694 cites W2769874317 @default.
- W4366076694 cites W2774823587 @default.
- W4366076694 cites W2785621845 @default.
- W4366076694 cites W2797295904 @default.
- W4366076694 cites W2802035813 @default.
- W4366076694 cites W2804598975 @default.
- W4366076694 cites W3102074109 @default.
- W4366076694 cites W4211212333 @default.
- W4366076694 cites W4233505570 @default.
- W4366076694 cites W4235692904 @default.
- W4366076694 doi "https://doi.org/10.1002/ange.201807029" @default.
- W4366076694 hasPublicationYear "2018" @default.
- W4366076694 type Work @default.
- W4366076694 citedByCount "28" @default.
- W4366076694 countsByYear W43660766942019 @default.
- W4366076694 countsByYear W43660766942020 @default.
- W4366076694 countsByYear W43660766942021 @default.
- W4366076694 countsByYear W43660766942022 @default.
- W4366076694 countsByYear W43660766942023 @default.
- W4366076694 crossrefType "journal-article" @default.
- W4366076694 hasAuthorship W4366076694A5024329973 @default.
- W4366076694 hasAuthorship W4366076694A5046044920 @default.
- W4366076694 hasAuthorship W4366076694A5065609760 @default.
- W4366076694 hasAuthorship W4366076694A5090997817 @default.
- W4366076694 hasConcept C104317684 @default.
- W4366076694 hasConcept C110879396 @default.
- W4366076694 hasConcept C121332964 @default.
- W4366076694 hasConcept C124668440 @default.