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• W4366082677 endingPage "e0282349" @default.
• W4366082677 startingPage "e0282349" @default.
• W4366082677 abstract "Sex hormones can affect cellular physiology and modulate synaptic plasticity, but it is not always clear whether or how sex-dependent differences identified in vitro express themselves as functional dimorphisms in the brain. Historically, most experimental neuroscience has been conducted using only male animals and the literature is largely mute about whether including female mice in will introduce variability due to inherent sex differences or endogenous estrous cycles. Though this is beginning to change following an NIH directive that sex should be included as a factor in vertebrate research, the lack of information raises practical issues around how to design experimental controls and apply existing knowledge to more heterogeneous populations. Various lines of research suggest that visual processing can be affected by sex and estrous cycle stage. For these reasons, we performed a series of in vivo electrophysiological experiments to characterize baseline visual function and experience-dependent plasticity in the primary visual cortex (V1) of male and female mice. We find that sex and estrous stage have no statistically significant effect on baseline acuity measurements, but that both sex and estrous stage have can modulate two mechanistically distinct forms of experience dependent cortical plasticity. We also demonstrate that resulting variability can be largely controlled with appropriate normalizations. These findings suggest that V1 plasticity can be used for mechanistic studies focusing on how sex hormones effect experience dependent plasticity in the mammalian cortex." @default.
• W4366082677 created "2023-04-19" @default.
• W4366082677 creator A5021412215 @default.
• W4366082677 creator A5034050670 @default.
• W4366082677 creator A5041904510 @default.
• W4366082677 date "2023-04-17" @default.
• W4366082677 modified "2023-09-26" @default.
• W4366082677 title "Sex and estrous cycle affect experience-dependent plasticity in mouse primary visual cortex" @default.
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