Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366083046> ?p ?o ?g. }
- W4366083046 endingPage "C28" @default.
- W4366083046 startingPage "C17" @default.
- W4366083046 abstract "G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the human genome. Even though perhaps 30% of approved medications target GPCRs, they interact with only a small number of them. Here, we consider whether there might be new opportunities for transformative therapeutics for neuropsychiatric disorders by specifically targeting both known and understudied GPCRs. Using psychedelic drugs that target serotonin receptors as an example, we show how recent insights into the structure, function, signaling, and cell biology of these receptors have led to potentially novel therapeutics. We next focus on the possibility that nonpsychedelic 5-HT2A receptor agonists might prove to be safe and rapidly acting antidepressants. Finally, we examine understudied and orphan GPCRs using the MRGPR family of receptors as an example." @default.
- W4366083046 created "2023-04-19" @default.
- W4366083046 creator A5007856961 @default.
- W4366083046 creator A5027073145 @default.
- W4366083046 date "2023-07-01" @default.
- W4366083046 modified "2023-10-13" @default.
- W4366083046 title "G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics" @default.
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