Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366083630> ?p ?o ?g. }
- W4366083630 abstract "Abstract Amyloid β (Aβ) is the major constituent in senile plaques of Alzheimer's disease in which peptides initially undergo structural conversions to form elongated fibrils. The impact of crowding on the fibrillation pathways of Aβ 40 and Aβ 42 , the most common peptide isoforms are studied. PEG and Ficoll are used as model crowders to mimic a macromolecular enriched surrounding. The fibrillar growth is monitored with the help of ThT‐fluorescence assays in order to extract two rates describing primary and secondary processes of nucleation and growth. Techniques as fluorescence correlation spectroscopy and analytical ultracentrifugation are used to discuss oligomeric states; fibril morphologies are investigated using negative‐staining transmission electron microscopy. While excluded volume effects imposed by macromolecular crowding are expected to always increase rates of intermolecular interactions and structural conversion, a vast variety of effects are found depending on the peptide, the crowder, or ionic strength of the solution. While investigations of the obtained rates with respect to a reactant‐occluded model are capable to display specific surface interactions with the crowder, the employment of crystallization‐like models reveal the crowder‐induced entropic gain with J mol −1 per volume fraction of the crowder." @default.
- W4366083630 created "2023-04-19" @default.
- W4366083630 creator A5004162618 @default.
- W4366083630 creator A5019872414 @default.
- W4366083630 creator A5056700477 @default.
- W4366083630 creator A5063160681 @default.
- W4366083630 creator A5069913264 @default.
- W4366083630 creator A5077620732 @default.
- W4366083630 date "2023-05-16" @default.
- W4366083630 modified "2023-10-14" @default.
- W4366083630 title "Inherent Adaptivity of Alzheimer Peptides to Crowded Environments" @default.
- W4366083630 cites W1961186421 @default.
- W4366083630 cites W1965219278 @default.
- W4366083630 cites W1970946380 @default.
- W4366083630 cites W1975317507 @default.
- W4366083630 cites W1976488701 @default.
- W4366083630 cites W1982999905 @default.
- W4366083630 cites W1988377264 @default.
- W4366083630 cites W1991388423 @default.
- W4366083630 cites W1992287344 @default.
- W4366083630 cites W2012500478 @default.
- W4366083630 cites W2012591531 @default.
- W4366083630 cites W2015675204 @default.
- W4366083630 cites W2030325989 @default.
- W4366083630 cites W2033212454 @default.
- W4366083630 cites W2034728705 @default.
- W4366083630 cites W2041070854 @default.
- W4366083630 cites W2043021835 @default.
- W4366083630 cites W2046847750 @default.
- W4366083630 cites W2049421402 @default.
- W4366083630 cites W2053202443 @default.
- W4366083630 cites W2061657038 @default.
- W4366083630 cites W2062111121 @default.
- W4366083630 cites W2064187550 @default.
- W4366083630 cites W2065586627 @default.
- W4366083630 cites W2073813663 @default.
- W4366083630 cites W2085467932 @default.
- W4366083630 cites W2086278983 @default.
- W4366083630 cites W2088577455 @default.
- W4366083630 cites W2093861673 @default.
- W4366083630 cites W2096601751 @default.
- W4366083630 cites W2098004479 @default.
- W4366083630 cites W2112154838 @default.
- W4366083630 cites W2134972813 @default.
- W4366083630 cites W2135370282 @default.
- W4366083630 cites W2144535585 @default.
- W4366083630 cites W2144579106 @default.
- W4366083630 cites W2162741488 @default.
- W4366083630 cites W2165021720 @default.
- W4366083630 cites W2165186407 @default.
- W4366083630 cites W2165360511 @default.
- W4366083630 cites W2168017678 @default.
- W4366083630 cites W2171413096 @default.
- W4366083630 cites W2306350765 @default.
- W4366083630 cites W2313725855 @default.
- W4366083630 cites W2339744412 @default.
- W4366083630 cites W2610052003 @default.
- W4366083630 cites W2614961214 @default.
- W4366083630 cites W2766991252 @default.
- W4366083630 cites W2771230435 @default.
- W4366083630 cites W2807184128 @default.
- W4366083630 cites W2884749741 @default.
- W4366083630 cites W2971898228 @default.
- W4366083630 cites W2972096612 @default.
- W4366083630 cites W2973920126 @default.
- W4366083630 cites W2979366099 @default.
- W4366083630 cites W3011513430 @default.
- W4366083630 cites W3014942842 @default.
- W4366083630 cites W3015856745 @default.
- W4366083630 cites W3024506966 @default.
- W4366083630 cites W3084144361 @default.
- W4366083630 cites W3111106506 @default.
- W4366083630 cites W3113311955 @default.
- W4366083630 cites W3119202068 @default.
- W4366083630 cites W3200190491 @default.
- W4366083630 cites W4229009865 @default.
- W4366083630 cites W4288722968 @default.
- W4366083630 cites W4303856973 @default.
- W4366083630 doi "https://doi.org/10.1002/mabi.202200527" @default.
- W4366083630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37066978" @default.
- W4366083630 hasPublicationYear "2023" @default.
- W4366083630 type Work @default.
- W4366083630 citedByCount "0" @default.
- W4366083630 crossrefType "journal-article" @default.
- W4366083630 hasAuthorship W4366083630A5004162618 @default.
- W4366083630 hasAuthorship W4366083630A5019872414 @default.
- W4366083630 hasAuthorship W4366083630A5056700477 @default.
- W4366083630 hasAuthorship W4366083630A5063160681 @default.
- W4366083630 hasAuthorship W4366083630A5069913264 @default.
- W4366083630 hasAuthorship W4366083630A5077620732 @default.
- W4366083630 hasBestOaLocation W43660836301 @default.
- W4366083630 hasConcept C121332964 @default.
- W4366083630 hasConcept C12554922 @default.
- W4366083630 hasConcept C136238340 @default.
- W4366083630 hasConcept C144618238 @default.
- W4366083630 hasConcept C147259501 @default.
- W4366083630 hasConcept C148898269 @default.
- W4366083630 hasConcept C178790620 @default.
- W4366083630 hasConcept C179104552 @default.
- W4366083630 hasConcept C181990884 @default.