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- W4366090861 endingPage "1182" @default.
- W4366090861 startingPage "1182" @default.
- W4366090861 abstract "Triple-negative breast cancer (TNBC) lacks estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expressions, making targeted therapies ineffective. Mesenchymal stem cells (MSCs) have emerged as a promising approach for TNBC treatment by modulating the tumor microenvironment (TME) and interacting with cancer cells. This review aims to comprehensively overview the role of MSCs in TNBC treatment, including their mechanisms of action and application strategies. We analyze the interactions between MSC and TNBC cells, including the impact of MSCs on TNBC cell proliferation, migration, invasion, metastasis, angiogenesis, and drug resistance, along with the signaling pathways and molecular mechanisms involved. We also explore the impact of MSCs on other components of the TME, such as immune and stromal cells, and the underlying mechanisms. The review discusses the application strategies of MSCs in TNBC treatment, including their use as cell or drug carriers and the advantages and limitations of different types and sources of MSCs in terms of safety and efficacy. Finally, we discuss the challenges and prospects of MSCs in TNBC treatment and propose potential solutions or improvement methods. Overall, this review provides valuable insights into the potential of MSCs as a novel therapeutic approach for TNBC treatment." @default.
- W4366090861 created "2023-04-19" @default.
- W4366090861 creator A5012585441 @default.
- W4366090861 creator A5042136599 @default.
- W4366090861 creator A5042612782 @default.
- W4366090861 creator A5047977691 @default.
- W4366090861 date "2023-04-15" @default.
- W4366090861 modified "2023-09-30" @default.
- W4366090861 title "From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer" @default.
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- W4366090861 doi "https://doi.org/10.3390/biomedicines11041182" @default.