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- W4366091843 endingPage "1043" @default.
- W4366091843 startingPage "1043" @default.
- W4366091843 abstract "Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still lacking a safe and effective vaccine for humans. Given this scenario, the search for a new prophylaxis alternative for controlling leishmaniasis should be a global priority. Inspired by leishmanization—a first generation vaccine strategy where live L. major parasites are inoculated in the skin to protect against reinfection—live-attenuated Leishmania vaccine candidates are promising alternatives due to their robust elicited protective immune response. In addition, they do not cause disease and could provide long-term protection upon challenge with a virulent strain. The discovery of a precise and easy way to perform CRISPR/Cas-based gene editing allowed the selection of safer null mutant live-attenuated Leishmania parasites obtained by gene disruption. Here, we revisited molecular targets associated with the selection of live-attenuated vaccinal strains, discussing their function, their limiting factors and the ideal candidate for the next generation of genetically engineered live-attenuated Leishmania vaccines to control leishmaniasis." @default.
- W4366091843 created "2023-04-19" @default.
- W4366091843 creator A5028033977 @default.
- W4366091843 creator A5059454512 @default.
- W4366091843 creator A5067828575 @default.
- W4366091843 date "2023-04-16" @default.
- W4366091843 modified "2023-09-29" @default.
- W4366091843 title "Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated Leishmania" @default.
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