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• W4366124138 abstract "BackgroundRezivertinib (BPI-7711) is a novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) which revealed the systematic and central nervous system (CNS) antitumor activities for EGFR T790M-mutated advanced NSCLC in previous clinical studies and is further analyzed here.MethodsEligible patients from the previous phase I and phase IIb studies of rezivertinib were included for pooled analysis. Post-progressive patients who received a prescribed dosage (≥180 mg) of rezivertinib orally once daily were included in full analysis set (FAS), while those with stable, asymptomatic CNS lesions, including measurable and non-measurable ones at baseline were included in CNS full analysis set (cFAS). Patients with measurable CNS lesions were included in CNS evaluable for response set (cEFR). BICR-assessed CNS objective response rate (CNS-ORR), CNS disease control rate (CNS-DCR), CNS duration of response (CNS-DoR), CNS progression-free survival (CNS-PFS), and CNS depth of response (CNS-DepOR) were evaluated.Results355 patients were included in FAS, among whom 150 and 45 patients were included in cFAS and cEFR. This pooled analysis showed the CNS-ORR was 32.0% (48/150; 95% CI: 24.6–40.1%) and the CNS-DCR was 42.0% (63/150; 95% CI: 34.0–50.3%) in cFAS, while that in cEFR were 68.9% (31/45; 95% CI: 53.4–81.8%) and 100% (45/45; 95% CI: 92.1–100.0%). In cEFR, the median CNS-DepOR and the mean of CNS-DepOR were -52.0% (range: -100.0 to 16.1%) and -46.8% (95% CI: –55.5 to -38.1%). In cFAS, the median CNS-DoR and CNS-PFS were 13.8 (95% CI: 9.6-not calculable [NC]) and 16.5 (95% CI: 13.7-NC) months.ConclusionsRezivertinib demonstrated encouraging clinical CNS efficacy among advanced NSCLC patients with EGFR T790M mutation and CNS metastases." @default.
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• W4366124138 date "2023-06-01" @default.
• W4366124138 modified "2023-10-17" @default.
• W4366124138 title "Central nervous system efficacy of rezivertinib (BPI-7711) in advanced NSCLC patients with EGFR T790M mutation: A pooled analysis of two clinical studies" @default.
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• W4366124138 cites W2560717039 @default.
• W4366124138 cites W2770828094 @default.
• W4366124138 cites W2776194348 @default.
• W4366124138 cites W2795708883 @default.
• W4366124138 cites W2887416920 @default.
• W4366124138 cites W2888877308 @default.
• W4366124138 cites W2900712986 @default.
• W4366124138 cites W2902378590 @default.
• W4366124138 cites W2990041408 @default.
• W4366124138 cites W3003752578 @default.
• W4366124138 cites W3083988862 @default.
• W4366124138 cites W3096583666 @default.
• W4366124138 cites W3150444504 @default.
• W4366124138 cites W3158400448 @default.
• W4366124138 cites W3212545260 @default.
• W4366124138 cites W4206811109 @default.
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• W4366124138 cites W4281984185 @default.
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• W4366124138 cites W4283812058 @default.
• W4366124138 cites W4289597577 @default.
• W4366124138 cites W4293857497 @default.
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• W4366124138 cites W4312114336 @default.
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• W4366124138 doi "https://doi.org/10.1016/j.lungcan.2023.107194" @default.
• W4366124138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37163774" @default.
• W4366124138 hasPublicationYear "2023" @default.
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