FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366124387> ?p ?o ?g. }

• W4366124387 endingPage "137259" @default.
• W4366124387 startingPage "137259" @default.
• W4366124387 abstract "Postoperative cognitive dysfunction (POCD) is common in aged patients after major surgery and is associated with increased risk of long-term morbidity and mortality. However, the underlying mechanism remains largely unknown and the clinical management of POCD is still controversial. Stellate ganglion block (SGB) is a clinical treatment for nerve injuries and circulatory issues. Recent evidence has identified the benefits of SGB in promoting learning and memory. We thus hypothesize that SGB could be effective in improving cognitive function after surgery. In present study, we established POCD model in aged rats via partial liver resection surgery. We found that the development of POCD was associated with the activation of toll-like receptor 4/nuclear factor kapa-B (TLR4/NF-κB) signaling pathway in the microglia in dorsal hippocampus, which induced the production of pro-inflammatory mediators (TNF-α, IL-1β, IL-6) and promoted neuroinflammation. More importantly, we showed evidence that preoperative treatment with SGB could inhibit microglial activation, suppress TLR4/NF-κB-mediated neuroinflammation and effectively attenuate cognitive decline after the surgery. Our study suggested that SGB may serve as a novel treatment to prevent POCD in elderly patients. As SGB is safe procedure widely used in clinic, our findings can be easily translated into clinical practice and benefit more patients." @default.
• W4366124387 created "2023-04-19" @default.
• W4366124387 creator A5013249496 @default.
• W4366124387 creator A5025105633 @default.
• W4366124387 creator A5041435329 @default.
• W4366124387 creator A5052676364 @default.
• W4366124387 creator A5058743657 @default.
• W4366124387 creator A5064228123 @default.
• W4366124387 creator A5069299629 @default.
• W4366124387 creator A5074700955 @default.
• W4366124387 date "2023-06-01" @default.
• W4366124387 modified "2023-09-27" @default.
• W4366124387 title "Stellate ganglion block alleviates postoperative cognitive dysfunction via inhibiting TLR4/NF-κB signaling pathway" @default.
• W4366124387 cites W1184688904 @default.
• W4366124387 cites W1539080042 @default.
• W4366124387 cites W1973553804 @default.
• W4366124387 cites W1995641070 @default.
• W4366124387 cites W2080903945 @default.
• W4366124387 cites W2083990390 @default.
• W4366124387 cites W2096298587 @default.
• W4366124387 cites W2104117223 @default.
• W4366124387 cites W2105715916 @default.
• W4366124387 cites W2149889696 @default.
• W4366124387 cites W2170543217 @default.
• W4366124387 cites W2300114742 @default.
• W4366124387 cites W2328842483 @default.
• W4366124387 cites W2344614872 @default.
• W4366124387 cites W2484256475 @default.
• W4366124387 cites W2604235446 @default.
• W4366124387 cites W2620901112 @default.
• W4366124387 cites W2751494359 @default.
• W4366124387 cites W2770981654 @default.
• W4366124387 cites W2787911242 @default.
• W4366124387 cites W2808555578 @default.
• W4366124387 cites W2900441263 @default.
• W4366124387 cites W2911127509 @default.
• W4366124387 cites W2936448260 @default.
• W4366124387 cites W3036721997 @default.
• W4366124387 cites W3050737291 @default.
• W4366124387 cites W3085901272 @default.
• W4366124387 cites W3153699994 @default.
• W4366124387 cites W3213844437 @default.
• W4366124387 cites W4200300483 @default.
• W4366124387 cites W4211043473 @default.
• W4366124387 cites W4285729717 @default.
• W4366124387 doi "https://doi.org/10.1016/j.neulet.2023.137259" @default.
• W4366124387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37075883" @default.
• W4366124387 hasPublicationYear "2023" @default.
• W4366124387 type Work @default.
• W4366124387 citedByCount "0" @default.
• W4366124387 crossrefType "journal-article" @default.
• W4366124387 hasAuthorship W4366124387A5013249496 @default.
• W4366124387 hasAuthorship W4366124387A5025105633 @default.
• W4366124387 hasAuthorship W4366124387A5041435329 @default.
• W4366124387 hasAuthorship W4366124387A5052676364 @default.
• W4366124387 hasAuthorship W4366124387A5058743657 @default.
• W4366124387 hasAuthorship W4366124387A5064228123 @default.
• W4366124387 hasAuthorship W4366124387A5069299629 @default.
• W4366124387 hasAuthorship W4366124387A5074700955 @default.
• W4366124387 hasConcept C118552586 @default.
• W4366124387 hasConcept C126322002 @default.
• W4366124387 hasConcept C142724271 @default.
• W4366124387 hasConcept C15744967 @default.
• W4366124387 hasConcept C169760540 @default.
• W4366124387 hasConcept C169900460 @default.
• W4366124387 hasConcept C204787440 @default.
• W4366124387 hasConcept C2776070231 @default.
• W4366124387 hasConcept C2776914184 @default.
• W4366124387 hasConcept C2777992791 @default.
• W4366124387 hasConcept C2779134260 @default.
• W4366124387 hasConcept C2779483572 @default.
• W4366124387 hasConcept C2779830541 @default.
• W4366124387 hasConcept C2780043718 @default.
• W4366124387 hasConcept C2984863031 @default.
• W4366124387 hasConcept C42219234 @default.
• W4366124387 hasConcept C71924100 @default.
• W4366124387 hasConcept C87753298 @default.
• W4366124387 hasConceptScore W4366124387C118552586 @default.
• W4366124387 hasConceptScore W4366124387C126322002 @default.
• W4366124387 hasConceptScore W4366124387C142724271 @default.
• W4366124387 hasConceptScore W4366124387C15744967 @default.
• W4366124387 hasConceptScore W4366124387C169760540 @default.
• W4366124387 hasConceptScore W4366124387C169900460 @default.
• W4366124387 hasConceptScore W4366124387C204787440 @default.
• W4366124387 hasConceptScore W4366124387C2776070231 @default.
• W4366124387 hasConceptScore W4366124387C2776914184 @default.
• W4366124387 hasConceptScore W4366124387C2777992791 @default.
• W4366124387 hasConceptScore W4366124387C2779134260 @default.
• W4366124387 hasConceptScore W4366124387C2779483572 @default.
• W4366124387 hasConceptScore W4366124387C2779830541 @default.
• W4366124387 hasConceptScore W4366124387C2780043718 @default.
• W4366124387 hasConceptScore W4366124387C2984863031 @default.
• W4366124387 hasConceptScore W4366124387C42219234 @default.
• W4366124387 hasConceptScore W4366124387C71924100 @default.
• W4366124387 hasConceptScore W4366124387C87753298 @default.
• W4366124387 hasLocation W43661243871 @default.
• W4366124387 hasLocation W43661243872 @default.
• W4366124387 hasOpenAccess W4366124387 @default.

• next