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- W4366132258 abstract "The expression of MHC-II and CD86 on the surface of antigen-presenting cells (APCs) must be tightly regulated to foster antigen-specific CD4 T-cell activation and to prevent autoimmunity. Surface expression of these proteins is regulated by their dynamic ubiquitination by the E3 ubiquitin ligase March-I. March-I promotes turnover of peptide–MHC-II complexes on resting APCs and termination of March-I expression promotes MHC-II and CD86 surface stability. In this review, we will highlight recent studies examining March-I function in both normal and pathological conditions." @default.
- W4366132258 created "2023-04-19" @default.
- W4366132258 creator A5029421637 @default.
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- W4366132258 date "2023-06-01" @default.
- W4366132258 modified "2023-09-29" @default.
- W4366132258 title "Regulation of MHC class II and CD86 expression by March-I in immunity and disease" @default.
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- W4366132258 doi "https://doi.org/10.1016/j.coi.2023.102325" @default.
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