FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366134202> ?p ?o ?g. }

• W4366134202 endingPage "114416" @default.
• W4366134202 startingPage "114416" @default.
• W4366134202 abstract "We investigated whether weight maintenance following short-term caloric restriction or exercise exerted neuroprotective effects on obesity induced by a high-fat diet. We also sought to identify whether the neuroprotective effects of higher untrained fitness persisted in the obese condition, both with and without caloric restriction or exercise. Male Wistar rats were fed with either a normal diet (ND) or a high-fat diet (HFD) for 12 weeks. At week 12, untrained fitness and blood metabolic parameters were measured. The ND-fed rats continuously received a ND for 16 additional weeks. HFD-fed rats were randomly assigned to 5 groups as of the followings: 1) an additional 16 weeks of HFD without intervention, 2) 10-week weight maintenance following 6-week short-term caloric restriction, 3) long-term caloric restriction (16 weeks), 4) 10-week weight maintenance following 6 weeks of HFD plus short-term exercise, and 5) HFD plus long-term exercise (16 weeks). Untrained fitness, blood metabolic parameters, and behavioral tests were then determined. Thereafter, the rats were euthanized for molecular studies. Our results demonstrated that long-term caloric restriction had the greatest systemic metabolic benefit among all interventions. Long-term caloric restriction and exercise equally attenuated HFD-induced cognitive impairment by improving synaptic function, blood-brain barrier integrity, mitochondrial health, and neurogenesis, and reducing oxidative stress, neuroinflammation, apoptosis, and Alzheimer's-related pathology. Weight maintenance following short-term caloric restriction showed no benefit to neurogenesis. Weight maintenance following short-term exercise exerted no benefit on synaptic function, neuronal insulin signaling and metabolism, autophagy, and neurogenesis. Interestingly, we found that higher untrained fitness level at week 12 showed positive correlations with more favorable brain profiles at week 28 in HFD-fed rats, both with and without caloric restriction or exercise. All of these findings suggested that higher untrained fitness exerts neuroprotection in HFD-induced obesity independently of caloric restriction or exercise. Therefore, targeting enhancement of untrained fitness may lead to more effective treatment of neurodegeneration in obese condition." @default.
• W4366134202 created "2023-04-19" @default.
• W4366134202 creator A5006772140 @default.
• W4366134202 creator A5025939163 @default.
• W4366134202 creator A5030219645 @default.
• W4366134202 creator A5053432872 @default.
• W4366134202 creator A5060709100 @default.
• W4366134202 creator A5074956117 @default.
• W4366134202 creator A5078255534 @default.
• W4366134202 creator A5087176240 @default.
• W4366134202 date "2023-07-01" @default.
• W4366134202 modified "2023-10-16" @default.
• W4366134202 title "Higher untrained fitness exerts a neuroprotection in Independence to caloric restriction or exercise in high-fat diet-induced obesity" @default.
• W4366134202 cites W1780379214 @default.
• W4366134202 cites W1886532160 @default.
• W4366134202 cites W1995614778 @default.
• W4366134202 cites W2004401015 @default.
• W4366134202 cites W2016752484 @default.
• W4366134202 cites W2060911425 @default.
• W4366134202 cites W2095536075 @default.
• W4366134202 cites W2112024831 @default.
• W4366134202 cites W2116404316 @default.
• W4366134202 cites W2122456662 @default.
• W4366134202 cites W2127225454 @default.
• W4366134202 cites W2151672477 @default.
• W4366134202 cites W2153273386 @default.
• W4366134202 cites W2155641294 @default.
• W4366134202 cites W2165734788 @default.
• W4366134202 cites W2167607159 @default.
• W4366134202 cites W2193466021 @default.
• W4366134202 cites W2231944090 @default.
• W4366134202 cites W2275191480 @default.
• W4366134202 cites W2307324788 @default.
• W4366134202 cites W2311617762 @default.
• W4366134202 cites W2315839070 @default.
• W4366134202 cites W2343436450 @default.
• W4366134202 cites W2481106179 @default.
• W4366134202 cites W2531439903 @default.
• W4366134202 cites W2531756294 @default.
• W4366134202 cites W2609511098 @default.
• W4366134202 cites W2613248673 @default.
• W4366134202 cites W2615792377 @default.
• W4366134202 cites W2625887862 @default.
• W4366134202 cites W267308069 @default.
• W4366134202 cites W2756811299 @default.
• W4366134202 cites W2770053197 @default.
• W4366134202 cites W2903363645 @default.
• W4366134202 cites W2914053210 @default.
• W4366134202 cites W2915130460 @default.
• W4366134202 cites W2917899491 @default.
• W4366134202 cites W2923349508 @default.
• W4366134202 cites W2937046550 @default.
• W4366134202 cites W2943624362 @default.
• W4366134202 cites W2963504600 @default.
• W4366134202 cites W2972216479 @default.
• W4366134202 cites W2981903281 @default.
• W4366134202 cites W2988644420 @default.
• W4366134202 cites W2993088619 @default.
• W4366134202 cites W3016883730 @default.
• W4366134202 cites W3043249795 @default.
• W4366134202 cites W3043402619 @default.
• W4366134202 cites W3044060299 @default.
• W4366134202 cites W3044958746 @default.
• W4366134202 cites W3092408711 @default.
• W4366134202 cites W3093157580 @default.
• W4366134202 cites W3118415136 @default.
• W4366134202 cites W3180288508 @default.
• W4366134202 cites W3186223729 @default.
• W4366134202 cites W4221097032 @default.
• W4366134202 cites W4298564356 @default.
• W4366134202 cites W620482152 @default.
• W4366134202 cites W79782691 @default.
• W4366134202 doi "https://doi.org/10.1016/j.expneurol.2023.114416" @default.
• W4366134202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37075969" @default.
• W4366134202 hasPublicationYear "2023" @default.
• W4366134202 type Work @default.
• W4366134202 citedByCount "0" @default.
• W4366134202 crossrefType "journal-article" @default.
• W4366134202 hasAuthorship W4366134202A5006772140 @default.
• W4366134202 hasAuthorship W4366134202A5025939163 @default.
• W4366134202 hasAuthorship W4366134202A5030219645 @default.
• W4366134202 hasAuthorship W4366134202A5053432872 @default.
• W4366134202 hasAuthorship W4366134202A5060709100 @default.
• W4366134202 hasAuthorship W4366134202A5074956117 @default.
• W4366134202 hasAuthorship W4366134202A5078255534 @default.
• W4366134202 hasAuthorship W4366134202A5087176240 @default.
• W4366134202 hasConcept C126322002 @default.
• W4366134202 hasConcept C134018914 @default.
• W4366134202 hasConcept C149984733 @default.
• W4366134202 hasConcept C15744967 @default.
• W4366134202 hasConcept C169760540 @default.
• W4366134202 hasConcept C190362976 @default.
• W4366134202 hasConcept C25498285 @default.
• W4366134202 hasConcept C4746552 @default.
• W4366134202 hasConcept C511355011 @default.
• W4366134202 hasConcept C544821477 @default.
• W4366134202 hasConcept C71924100 @default.
• W4366134202 hasConceptScore W4366134202C126322002 @default.

• next