FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366152489> ?p ?o ?g. }

• W4366152489 endingPage "436" @default.
• W4366152489 startingPage "431" @default.
• W4366152489 abstract "The Manchester Acute Coronary Syndromes ECG (MACS-ECG) prediction model calculates a score based on objective ECG measurements to give the probability of a non-ST elevation myocardial infarction (NSTEMI). The model showed good performance in the emergency department (ED), but its accuracy in the pre-hospital setting is unknown. We aimed to externally validate MACS-ECG in the pre-hospital environment.We undertook a secondary analysis from the Pre-hospital Evaluation of Sensitive Troponin (PRESTO) study, a multi-centre prospective study to validate decision aids in the pre-hospital setting (26 February 2019 to 23 March 2020). Patients with chest pain where the treating paramedic suspected acute coronary syndrome were included. Paramedics collected demographic and historical data and interpreted ECGs contemporaneously (as 'normal' or 'abnormal'). After completing recruitment, we analysed ECGs to calculate the MACS-ECG score, using both a pre-defined threshold and a novel threshold that optimises sensitivity to differentiate AMI from non-AMI. This was compared with subjective ECG interpretation by paramedics. The diagnosis of AMI was adjudicated by two investigators based on serial troponin testing in hospital.Of 691 participants, 87 had type 1 AMI and 687 had complete data for paramedic ECG interpretation. The MACS-ECG model had a C-index of 0.68 (95% CI: 0.61 to 0.75). At the pre-determined cut-off, MACS-ECG had 2.3% (95% CI: 0.3% to 8.1%) sensitivity, 99.5% (95% CI: 98.6% to 99.9%) specificity, 40.0% (95% CI: 10.2% to 79.3%) positive predictive value (PPV) and 87.6% (87.3% to 88.0%) negative predictive value (NPV). At the optimal threshold for sensitivity, MACS-ECG had 50.6% sensitivity (39.6% to 61.5%), 83.1% specificity (79.9% to 86.0%), 30.1% PPV (24.7% to 36.2%) and 92.1% NPV (90.4% to 93.5%). In comparison, paramedics had a sensitivity of 71.3% (95% CI: 60.8% to 80.5%) with 53.8% (95% CI: 53.8% to 61.8%) specificity, 19.7% (17.2% to 22.45%) PPV and 93.3% (90.8% to 95.1%) NPV.Neither MACS-ECG nor paramedic ECG interpretation had a sufficiently high PPV or NPV to 'rule in' or 'rule out' NSTEMI alone." @default.
• W4366152489 created "2023-04-19" @default.
• W4366152489 creator A5020618614 @default.
• W4366152489 creator A5020875420 @default.
• W4366152489 creator A5026108472 @default.
• W4366152489 creator A5026732839 @default.
• W4366152489 creator A5034594250 @default.
• W4366152489 creator A5051592046 @default.
• W4366152489 creator A5052442247 @default.
• W4366152489 creator A5069174713 @default.
• W4366152489 creator A5076200579 @default.
• W4366152489 creator A5077160653 @default.
• W4366152489 creator A5078427993 @default.
• W4366152489 creator A5086644674 @default.
• W4366152489 creator A5091093091 @default.
• W4366152489 creator A5091191993 @default.
• W4366152489 date "2023-04-17" @default.
• W4366152489 modified "2023-09-30" @default.
• W4366152489 title "External validation of the Manchester Acute Coronary Syndromes ECG risk model within a pre-hospital setting" @default.
• W4366152489 cites W2151226132 @default.
• W4366152489 cites W2332506458 @default.
• W4366152489 cites W2347184871 @default.
• W4366152489 cites W2888543854 @default.
• W4366152489 cites W2895624434 @default.
• W4366152489 cites W2909547463 @default.
• W4366152489 cites W2982643832 @default.
• W4366152489 cites W3042252249 @default.
• W4366152489 cites W3139190466 @default.
• W4366152489 cites W3205081326 @default.
• W4366152489 cites W4206537727 @default.
• W4366152489 cites W4223976760 @default.
• W4366152489 cites W4229080973 @default.
• W4366152489 cites W4311870352 @default.
• W4366152489 doi "https://doi.org/10.1136/emermed-2022-212872" @default.
• W4366152489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37068929" @default.
• W4366152489 hasPublicationYear "2023" @default.
• W4366152489 type Work @default.
• W4366152489 citedByCount "0" @default.
• W4366152489 crossrefType "journal-article" @default.
• W4366152489 hasAuthorship W4366152489A5020618614 @default.
• W4366152489 hasAuthorship W4366152489A5020875420 @default.
• W4366152489 hasAuthorship W4366152489A5026108472 @default.
• W4366152489 hasAuthorship W4366152489A5026732839 @default.
• W4366152489 hasAuthorship W4366152489A5034594250 @default.
• W4366152489 hasAuthorship W4366152489A5051592046 @default.
• W4366152489 hasAuthorship W4366152489A5052442247 @default.
• W4366152489 hasAuthorship W4366152489A5069174713 @default.
• W4366152489 hasAuthorship W4366152489A5076200579 @default.
• W4366152489 hasAuthorship W4366152489A5077160653 @default.
• W4366152489 hasAuthorship W4366152489A5078427993 @default.
• W4366152489 hasAuthorship W4366152489A5086644674 @default.
• W4366152489 hasAuthorship W4366152489A5091093091 @default.
• W4366152489 hasAuthorship W4366152489A5091191993 @default.
• W4366152489 hasBestOaLocation W43661524891 @default.
• W4366152489 hasConcept C118552586 @default.
• W4366152489 hasConcept C126322002 @default.
• W4366152489 hasConcept C164705383 @default.
• W4366152489 hasConcept C188816634 @default.
• W4366152489 hasConcept C194828623 @default.
• W4366152489 hasConcept C2777120189 @default.
• W4366152489 hasConcept C2777698277 @default.
• W4366152489 hasConcept C2778704086 @default.
• W4366152489 hasConcept C2780724011 @default.
• W4366152489 hasConcept C36036425 @default.
• W4366152489 hasConcept C500558357 @default.
• W4366152489 hasConcept C71924100 @default.
• W4366152489 hasConceptScore W4366152489C118552586 @default.
• W4366152489 hasConceptScore W4366152489C126322002 @default.
• W4366152489 hasConceptScore W4366152489C164705383 @default.
• W4366152489 hasConceptScore W4366152489C188816634 @default.
• W4366152489 hasConceptScore W4366152489C194828623 @default.
• W4366152489 hasConceptScore W4366152489C2777120189 @default.
• W4366152489 hasConceptScore W4366152489C2777698277 @default.
• W4366152489 hasConceptScore W4366152489C2778704086 @default.
• W4366152489 hasConceptScore W4366152489C2780724011 @default.
• W4366152489 hasConceptScore W4366152489C36036425 @default.
• W4366152489 hasConceptScore W4366152489C500558357 @default.
• W4366152489 hasConceptScore W4366152489C71924100 @default.
• W4366152489 hasFunder F4320320291 @default.
• W4366152489 hasIssue "6" @default.
• W4366152489 hasLocation W43661524891 @default.
• W4366152489 hasLocation W43661524892 @default.
• W4366152489 hasLocation W43661524893 @default.
• W4366152489 hasOpenAccess W4366152489 @default.
• W4366152489 hasPrimaryLocation W43661524891 @default.
• W4366152489 hasRelatedWork W2014568956 @default.
• W4366152489 hasRelatedWork W2018147868 @default.
• W4366152489 hasRelatedWork W2069274614 @default.
• W4366152489 hasRelatedWork W2084334850 @default.
• W4366152489 hasRelatedWork W2140052087 @default.
• W4366152489 hasRelatedWork W23424313 @default.
• W4366152489 hasRelatedWork W2775636120 @default.
• W4366152489 hasRelatedWork W2790973215 @default.
• W4366152489 hasRelatedWork W3016959066 @default.
• W4366152489 hasRelatedWork W3046938773 @default.
• W4366152489 hasVolume "40" @default.
• W4366152489 isParatext "false" @default.
• W4366152489 isRetracted "false" @default.

• next