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- W4366163670 abstract "Chronic mental and physical fatigue and post-exertional malaise are the more debilitating symptoms of long COVID-19. The study objective was to explore factors contributing to exercise intolerance in long COVID-19 to guide development of new therapies. Exercise capacity data of patients referred for a cardiopulmonary exercise test (CPET) and included in a COVID-19 Survivorship Registry at one urban health center were retrospectively analyzed. Results: Most subjects did not meet normative criteria for a maximal test, consistent with suboptimal effort and early exercise termination. Mean O2 pulse peak % predicted (of 79 ± 12.9) was reduced, supporting impaired energy metabolism as a mechanism of exercise intolerance in long COVID, n = 59. We further identified blunted rise in heart rate peak during maximal CPET. Our preliminary analyses support therapies that optimize bioenergetics and improve oxygen utilization for treating long COVID-19." @default.
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- W4366163670 date "2023-07-01" @default.
- W4366163670 modified "2023-10-14" @default.
- W4366163670 title "Exercise intolerance associated with impaired oxygen extraction in patients with long COVID" @default.
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- W4366163670 doi "https://doi.org/10.1016/j.resp.2023.104062" @default.
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