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- W4366166783 endingPage "114828" @default.
- W4366166783 startingPage "114828" @default.
- W4366166783 abstract "Although several nanomedicines got clinical approval over the past two decades, the clinical translation rate is relatively small so far. There are many post-surveillance withdrawals of nanomedicines caused by various safety issues. For successful clinical advancement of nanotechnology, it is of unmet need to realize cellular and molecular foundation of nanotoxicity. Current data suggest that lysosomal dysfunction caused by nanoparticles is emerging as the most common intracellular trigger of nanotoxicity. This review analyzes prospect mechanisms of lysosomal dysfunction-mediated toxicity induced by nanoparticles. We summarized and critically assessed adverse drug reactions of current clinically approved nanomedicines. Importantly, we show that physicochemical properties have great impact on nanoparticles interaction with cells, excretion route and kinetics, and subsequently on toxicity. We analyzed literature on adverse reactions of current nanomedicines and hypothesized that adverse reactions might be linked with lysosomal dysfunction caused by nanomedicines. Finally, from our analysis it becomes clear that it is unjustifiable to generalize safety and toxicity of nanoparticles, since different particles possess distinct toxicological properties. We propose that the biological mechanism of the disease progression and treatment should be central in the optimization of nanoparticle design." @default.
- W4366166783 created "2023-04-19" @default.
- W4366166783 creator A5021283511 @default.
- W4366166783 creator A5025250994 @default.
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- W4366166783 creator A5061082419 @default.
- W4366166783 creator A5076890912 @default.
- W4366166783 creator A5081265979 @default.
- W4366166783 creator A5085840144 @default.
- W4366166783 date "2023-06-01" @default.
- W4366166783 modified "2023-10-17" @default.
- W4366166783 title "Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function" @default.
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