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- W4366171107 abstract "Acne is a common skin disease with a high psychosocial impact affecting adolescents worldwide. Management of acne vulgaris is often challenged by cutaneous side effects that leads to therapeutic intolerance, poor compliance and impaired efficacy. This was a single-center, evaluator-blinded, split-face, randomized trial investigating the effects of thermal spring water in improving efficacy and tolerability of standard acne therapy. A total of 31 participants with mild-to-moderate acne were recruited and subjected to thermal spring water spray to one side of the face 4 times daily for 6 weeks in addition to standard therapy. The other side received standard therapy only. Six(19.4%) males and 25(80.6%) female with mean age 25.1±6.13 participated, 10(32.3%) had mild while 16(51.6%) had moderate acne. Seven (22.6%) were on oral antibiotics, 25(80.6%) used adapalene, 6(19.4%) tretinoin and 21(67.7%) benzoyl peroxide. Stratum corneum hydration improved and was better on spring water treated side with mean difference 12.41±30.31,p=0.04 at the forehead, 39.52±65.14, <0.01 at the cheek and 42.172±71.71, p<0.01 at the jaw at week 6. Participants also report significant reduction in dryness at the treated side at week 6, mean difference 0.93±0.10, p<0.001. TEWL, sebum and pH were comparable on both sides with no significant differences. Tolerability towards standard therapy improved as early week 2 with reduction of stinging following application of topical therapy (mean difference 0.62±1.43, p=0.03), increase in skin feeling good (-1.79±1.70, p<0.001) and skin suppleness (0.62±1.43, p<0.001). These improvements were significantly maintained till week 6. Cardiff acne disability index significantly improved at week 6 despite no significant changes in Comprehensive Acne Severity Scale score before and after treatment. Thermal spring water has a role as an adjunct to standard acne therapy by improving hydration, acne disability index and tolerability towards standard topical treatment." @default.
- W4366171107 created "2023-04-19" @default.
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- W4366171107 date "2023-05-01" @default.
- W4366171107 modified "2023-09-26" @default.
- W4366171107 title "608 Effects of a Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris" @default.
- W4366171107 doi "https://doi.org/10.1016/j.jid.2023.03.615" @default.
- W4366171107 hasPublicationYear "2023" @default.
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