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- W4366171196 abstract "Psychological stress has multiple physiologic and clinical impacts on skin such as inflammation, itching, impair skin barrier function, provoking skin discomfort that can amplify psychological stress. We have developed a new active ingredient from Camellia oleifera seeds, tea oil concentrate (TOC), rich in unsaponifiable fraction. This active ingredient was evaluated in in vitro models mimicking the effects of stress in the skin. The effect of TOC was evaluated on IL1a release in reconstructed human epidermises (RHE) stimulated by PMA. To assess he activity of TOC on skin neurosensory system, TOC was applied on reinnervated epidermises and substance P release was measured by ELISA following lactic acid provocation. The efficacy of TOC was also investigated on cortisol release in skin explants stimulated by adrenocorticotropic hormone (ACTH) and temperature. The activity of TOC was finally studied on skin barrier function in skin explants subjected to stripping and cortisol stress. Our results show that tea oil concentrate significantly inhibited IL1a production induced by PMA in RHE model. TOC was able to significantly decrease the release of substance P induced by lactic acid in a reinnervated epidermis model. Moreover, TOC decreased the cortisol release stimulated by ACTH and temperature in skin explant model. TOC showed an efficacy in a skin explant model mimicking the effect of cortisol on skin barrier. Finally, TOC decreased the lucifer yellow permeability, indicating a better barrier integrity. To conclude, our new ingredient is able to inhibit the release of mediators involved in two stress response axis (cortisol and substance P). Moreover, it shows anti-inflammatory efficacy and can protect the skin barrier against cortisol stress. Taken together, these results show the potential of TOC to stop stress vicious circle and promote skin comfort." @default.
- W4366171196 created "2023-04-19" @default.
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- W4366171196 date "2023-05-01" @default.
- W4366171196 modified "2023-09-28" @default.
- W4366171196 title "792 Tea oil concentrate from camellia oleifera, obtained by molecular distillation, to improve skin comfort and well-being" @default.
- W4366171196 doi "https://doi.org/10.1016/j.jid.2023.03.801" @default.
- W4366171196 hasPublicationYear "2023" @default.
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