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- W4366171246 abstract "Psoriasis is an immune-mediated skin disease dominated by the cutaneous and systemic immune disorder. Skin cells including epidermal keratinocytes and innate immune cells play roles in psoriatic skin inflammation. The key molecules of keratinocytes that link the cutaneous immune system in psoriasis need be investigated more. Sprouty1 belongs to receptor tyrosine kinase (RTK) antagonist, which can inhibit mitogen-activated protein kinase (MAPK) signaling. Sprouty1 mainly expressed in granular layer of human skin epidermis, and granular layer cells are key structure of epidermal barrier. Damaged epidermal barrier and skin damage alarming molecules as antimicrobial peptides are important triggers of psoriasis initiation. In the biological functions of keratinocytes, we found Sprouty1 can inhibit cell proliferation, promote apoptosis, and regulate differentiation. However, Sprouty1 was decreased in psoriatic keratinocytes. Meanwhile, the expression of cathelicidin (camp/LL37) as one of antimicrobial peptides, was suppressed by Sprouty1 in mouse model. Moreover, mouse skin innate immune cells such as CD11b+CCR2+ dendritic cells, IL-17A+ γδT cells, and Ly6C+ CD11c+ monocyte-derived dendritic cells, are also decreased when Sprouty1 overexpressed in keratinocytes. These findings indicate that Sprouty1 can boost skin barrier function, also can stabilize cutaneous inflammation." @default.
- W4366171246 created "2023-04-19" @default.
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- W4366171246 date "2023-05-01" @default.
- W4366171246 modified "2023-09-28" @default.
- W4366171246 title "712 Sprouty1 boost epidermal barrier function and stabilize cutaneous innate immune in psoriasis" @default.
- W4366171246 doi "https://doi.org/10.1016/j.jid.2023.03.721" @default.
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