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- W4366171256 abstract "Squalene (SQ) is a lipid produced in sebaceous gland involved in the vital skin barrier function. Its peroxidation leads to the accumulation of SQ epoxides and monohydroperoxides causing various skin damages as hyperpigmentation, wrinkles, and acne. Monitoring the effects of a cosmetic cream on the evolution of lipid content and their oxidation during clinical studies represent numerous analysis; highlighting the need to combine molecule analyses in a single method. High Performance Liquid Chromatography (HPLC) coupled with Diode Array Detector (DAD) commonly allowed to detect SQ but is not sensitive enough for detection of oxidation products. On the other hand, SQ structure cannot be detected by Mass Spectrophotometer (MS) although it is more sensitive. The aim of this study was to propose a method to analyze SQ and its oxidation products within a single injection by coupling DAD and MS analyses. First, SQ standard was oxidized with hydrogen peroxide. Separation of the unoxidized SQ and the oxidation products was developed by HPLC-DAD-MS. It allowed to detect unoxidized SQ standard with DAD at 210 nm and identification of SQ peroxidation products with MS in electrospray ionization negative scan mode at m/z=409 and m/z=425. Indeed, a method of 41 minutes, including DAD detection at 210 nm and MS in single ion monitoring mode detection at m/z=409 and m/z=425 was validated to study simultaneously squalene and its peroxidation products. Secondly, the method obtained was applied to monitor the evolution of SQ, collected with sebutapes, on volunteers after application of a cream containing 1% Santalum album extract.Results collected have allowed to demonstrate anti-oxidation effect of the ingredient against squalene peroxidation. In conclusion, we developed a method to monitor SQ and its oxidation products by HPLC-DAD-MS in a single shot. This new method allows to study squalene and squalene oxidation in the skin of volunteers, by a non-invasive manner." @default.
- W4366171256 created "2023-04-19" @default.
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- W4366171256 date "2023-05-01" @default.
- W4366171256 modified "2023-09-28" @default.
- W4366171256 title "762 Analytical method to monitor squalene and its primary oxidation products by liquid chromatography coupled with both mass spectrometry and diode array detector" @default.
- W4366171256 doi "https://doi.org/10.1016/j.jid.2023.03.771" @default.
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