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• W4366171268 abstract "Background: Lamellar granules (LGs) are essential cell organelles secreted extracellularly and contribute to skin barrier function. Our previous 3D electron microscopy (EM) studies revealed that LGs remains in the cytoplasm in the 3rd layer from the surface of the epidermal granule layer, SG3, and that secretion toward the surface layer begins in the 2nd layer, SG2, with all granules secreted in the 1st layer, SG1. However, the details of the regulatory mechanism of secretion still need to be fully elucidated. Aim: To clarify the secretory regulation mechanism of LGs. Materials & Methods: Healthy human skin samples were subjected to 2D transmission EM (TEM) and 3DEM. For the latter, we used serial section scanning electron microscopy (SEM), which uses imaging of resin-embedded thin sections on glass slides. We cut 300 serial sections of 100 nm thickness and examined them by SEM. Granular cells, nuclei, and extracellular LGs were segmented, and 3D images were reconstructed. Results: 2DEM showed that when SG2 cells are in contact with multiple SG1 cells, the LG secretion does not occur uniformly on the underside of all SG1 cells in contact. In 2DEM, however, cellular phenomena are not always correctly reflected in a particular cross-section, and the positional relationship of multiple SG1 cells is uncertain. 3DEM revealed that if an SG2 cell faced two or more SG1 cells, secretion of LGs can be limited on the underside of a particular SG1 cell, that was located closer to the stratum corneum than the other SG1 cells. Conclusion: Granule cells may be able to sense the degree of cell differentiation with which they are in contact. 3DEM can be a powerful tool for unraveling skin biology." @default.
• W4366171268 created "2023-04-19" @default.
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• W4366171268 date "2023-05-01" @default.
• W4366171268 modified "2023-09-28" @default.
• W4366171268 title "733 3D electron microscopy revealed that lamellar granules are secreted on the underside of more matured granular cells" @default.
• W4366171268 doi "https://doi.org/10.1016/j.jid.2023.03.742" @default.
• W4366171268 hasPublicationYear "2023" @default.
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