Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366171451> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4366171451 endingPage "S133" @default.
- W4366171451 startingPage "S133" @default.
- W4366171451 abstract "Epidermal stability depends on keratin intermediate filaments, which form a trans-cellular mechanical scaffold. During epidermal remodeling, keratin filament composition shifts, with increased expression of five wound-associated keratin isoforms. However, the function of wound-associated keratins during epidermal remodeling remains unclear. Identifying isoform-specific keratin functions has been challenging, since depleting individual keratins compromises the more general mechanical scaffold function. To disentangle these effects, we take a gain-of-function rather than a loss-of-function approach. We find that increasing expression of wound-associated keratin 6A (K6A), but not steady-state K5, promotes keratinocyte migration, especially in stratified epidermal cultures. Using live imaging and traction force microscopy, we show that, rather than alter the keratin mechanical scaffold, K6A triggers signaling crosstalk with actomyosin to increase force generation. Unexpectedly, K6A promotes actomyosin contractility through a preferential interaction between the unstructured K6A head domain and a small pool of non-filamentous vimentin. K6A-enriched filaments and vimentin anchor a transient signaling complex spatially organizing myosin subunits and regulatory kinases to activate myosin. These results expand the functional repertoire of keratin filaments beyond their canonical role as mechanical scaffolds to include a role as signaling scaffolds, with activity tuned by the specific keratin isoforms expressed." @default.
- W4366171451 created "2023-04-19" @default.
- W4366171451 creator A5003343979 @default.
- W4366171451 creator A5010459208 @default.
- W4366171451 creator A5019333664 @default.
- W4366171451 creator A5030074533 @default.
- W4366171451 creator A5045073507 @default.
- W4366171451 creator A5090403710 @default.
- W4366171451 date "2023-05-01" @default.
- W4366171451 modified "2023-09-28" @default.
- W4366171451 title "776 A keratin switch promotes epidermal remodeling by organizing actomyosin-activating signals" @default.
- W4366171451 doi "https://doi.org/10.1016/j.jid.2023.03.785" @default.
- W4366171451 hasPublicationYear "2023" @default.
- W4366171451 type Work @default.
- W4366171451 citedByCount "0" @default.
- W4366171451 crossrefType "journal-article" @default.
- W4366171451 hasAuthorship W4366171451A5003343979 @default.
- W4366171451 hasAuthorship W4366171451A5010459208 @default.
- W4366171451 hasAuthorship W4366171451A5019333664 @default.
- W4366171451 hasAuthorship W4366171451A5030074533 @default.
- W4366171451 hasAuthorship W4366171451A5045073507 @default.
- W4366171451 hasAuthorship W4366171451A5090403710 @default.
- W4366171451 hasBestOaLocation W43661714511 @default.
- W4366171451 hasConcept C104317684 @default.
- W4366171451 hasConcept C108335385 @default.
- W4366171451 hasConcept C142669718 @default.
- W4366171451 hasConcept C147447768 @default.
- W4366171451 hasConcept C1491633281 @default.
- W4366171451 hasConcept C170178370 @default.
- W4366171451 hasConcept C185592680 @default.
- W4366171451 hasConcept C203014093 @default.
- W4366171451 hasConcept C204232928 @default.
- W4366171451 hasConcept C50548948 @default.
- W4366171451 hasConcept C53345823 @default.
- W4366171451 hasConcept C53645450 @default.
- W4366171451 hasConcept C54355233 @default.
- W4366171451 hasConcept C55493867 @default.
- W4366171451 hasConcept C62478195 @default.
- W4366171451 hasConcept C6997183 @default.
- W4366171451 hasConcept C78383274 @default.
- W4366171451 hasConcept C81241287 @default.
- W4366171451 hasConcept C86803240 @default.
- W4366171451 hasConcept C95444343 @default.
- W4366171451 hasConceptScore W4366171451C104317684 @default.
- W4366171451 hasConceptScore W4366171451C108335385 @default.
- W4366171451 hasConceptScore W4366171451C142669718 @default.
- W4366171451 hasConceptScore W4366171451C147447768 @default.
- W4366171451 hasConceptScore W4366171451C1491633281 @default.
- W4366171451 hasConceptScore W4366171451C170178370 @default.
- W4366171451 hasConceptScore W4366171451C185592680 @default.
- W4366171451 hasConceptScore W4366171451C203014093 @default.
- W4366171451 hasConceptScore W4366171451C204232928 @default.
- W4366171451 hasConceptScore W4366171451C50548948 @default.
- W4366171451 hasConceptScore W4366171451C53345823 @default.
- W4366171451 hasConceptScore W4366171451C53645450 @default.
- W4366171451 hasConceptScore W4366171451C54355233 @default.
- W4366171451 hasConceptScore W4366171451C55493867 @default.
- W4366171451 hasConceptScore W4366171451C62478195 @default.
- W4366171451 hasConceptScore W4366171451C6997183 @default.
- W4366171451 hasConceptScore W4366171451C78383274 @default.
- W4366171451 hasConceptScore W4366171451C81241287 @default.
- W4366171451 hasConceptScore W4366171451C86803240 @default.
- W4366171451 hasConceptScore W4366171451C95444343 @default.
- W4366171451 hasIssue "5" @default.
- W4366171451 hasLocation W43661714511 @default.
- W4366171451 hasOpenAccess W4366171451 @default.
- W4366171451 hasPrimaryLocation W43661714511 @default.
- W4366171451 hasRelatedWork W1747865689 @default.
- W4366171451 hasRelatedWork W1997469925 @default.
- W4366171451 hasRelatedWork W2000980346 @default.
- W4366171451 hasRelatedWork W2104635208 @default.
- W4366171451 hasRelatedWork W2149727923 @default.
- W4366171451 hasRelatedWork W2346944633 @default.
- W4366171451 hasRelatedWork W2394641631 @default.
- W4366171451 hasRelatedWork W2398194288 @default.
- W4366171451 hasRelatedWork W2891729009 @default.
- W4366171451 hasRelatedWork W330593879 @default.
- W4366171451 hasVolume "143" @default.
- W4366171451 isParatext "false" @default.
- W4366171451 isRetracted "false" @default.
- W4366171451 workType "article" @default.