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- W4366171497 abstract "Dry skin is a common skin disorder especially in the elderly and in patients with underlying medical conditions. The various exogenous and endogenous factors can trigger dryness caused by skin barrier disruption; however, a key regulator of barrier homeostasis still remains to be elucidated. In this study, we focused on the role of pericytes, known as multipotent perivascular cells, in dry skin on the bases of previous reports that (1) dermal pericyte numbers decrease with age in humans, and that (2) dermal pericytes regulate skin wound healing by increased angiogenesis and reduced inflammation. As a result, delipidized human skin following the application of acetone/methanol as a dry skin ex vivo model (Yokota et al., SID 2022), caused a significant reduction in the number of NG2+/Nestin+ (type-2) dermal pericytes, accompanied by an increased number of undifferentiated cells (Nestin+). When the conditioned media derived from the dry skin ex vivo model was applied to the spheroid-forming pericytes, the decrease of NG2 expression and the increase of Nestin expression were observed, suggesting that secretory factors promoted modification of undifferentiated cell state in the dry skin ex vivo model. Then, ex vivopericyte depletion by a neutralizing antibody against PDGFR-β resulted in skin barrier disruption, as determined by the claudin-1 and AQP3 immunoreactivities, and the penetration of a hydrophilic fluorescent dye across the stratum corneum on the tape strips. These results indicate that pericytes contribute to the maintenance of tight junction barrier integrity, and are thus a promising therapeutic target for dry skin." @default.
- W4366171497 created "2023-04-19" @default.
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- W4366171497 date "2023-05-01" @default.
- W4366171497 modified "2023-09-28" @default.
- W4366171497 title "798 A role for dermal pericytes on ex vivo human skin barrier function" @default.
- W4366171497 doi "https://doi.org/10.1016/j.jid.2023.03.807" @default.
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