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- W4366171856 abstract "To investigate the potential effects of long non-coding RNA X-inactive specific transcript (lncRNA XIST) on apoptosis imbalance of chronic actinc dermatitis (CAD) through targeted regulation of nuclear factor kB(NF-κB) pathway. From January 2017 to January 2018, 8 cases of CAD tissue and 8 cases of healthy controls were collected. XIST and NF-κB was focused through analyses of Genome-wide Analysis, qRT-PCR verification, Gene Ontology enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) and random gene set enrichment analysis (RGSEA). Luciferase reporter assay was used to validate specific regulation mechanism of XIST. Hacat cells were randomly divided into control group and transfection groups(siXIST+NC, siNF-κB+NC, siXIST+siNF-κB, XIST+siNF-κB, siXIST+NF-κB), apoptosis related genes were tested with qRT-PCR and western blot, flow cytometry with and EdU were conducted in order to study the definite effects on apoptosis imbalance. The study discovered XIST was obviously down-regulated in CAD tissues (p<0.05)and NF-κB pathway was distinctly enriched(p<0.05), which both related to apoptosis imbalance of CAD. The luciferase reporter assay confirmed that XIST regulate NF-κB pathway through XIST/miR511-5p/TNFAIP3 network. Down-regulated XIST can activate NF-κB pathway, promote proliferation and inhibit apoptosis. In one word, in the pathogenesis of CAD, down-regulation of lncRNA XIST trigger the activation of NF-κB signaling pathway through positive regulation of TNFAIP3, to induced the apoptosis imbalance of keratinocytes." @default.
- W4366171856 created "2023-04-19" @default.
- W4366171856 creator A5023226095 @default.
- W4366171856 date "2023-05-01" @default.
- W4366171856 modified "2023-09-28" @default.
- W4366171856 title "784 XIst regulate nuclear factor-κb pathway to participate apoptosis imbalance in chronic actinic dermatitis" @default.
- W4366171856 doi "https://doi.org/10.1016/j.jid.2023.03.793" @default.
- W4366171856 hasPublicationYear "2023" @default.
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