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- W4366172702 abstract "Sebaceous adenocarcinoma is a rare adnexal neoplasm. Both wide local excision (WLE) and Mohs micrographic surgery (MMS) have been shown to be effective treatment options, with some suggesting MMS may have lower rates of recurrence and metastasis. We sought to further characterize epidemiology of sebaceous adenocarcinoma and treatment with MMS in the US population. Data were collected from the Surveillance, Epidemiology, and End Results (SEER) database from 1975-2016. Patients with cutaneous sebaceous adenocarcinoma were identified within the SEER database using the ICD-03 code 8410/3, and primary site codes for skin. 4175 cases were identified. Majority occurred in individuals of male sex (59%), white race (91%), older age (average 70.9 years), and on the head and neck (75%). 85% were treated with surgical modalities. On univariate analysis, patients with older age, male sex, and higher tumor stage at presentation had poorer overall survival (OS) (p<0.05), while those who were married and received surgical intervention had improved OS (p<0.05). Survival outcomes were similar for those who received MMS or WLE. On multivariable logistic analysis, lower tumor stage and more recent year of diagnosis were associated with increased likelihood of receiving MMS, and location on the trunk or extremities with decreased likelihood as compared with the head and neck (p<0.05). Our results suggest MMS is being used more commonly for sebaceous adenocarcinoma, particularly on the head and neck as compared with the trunk, and more often for lower stage tumors. There was no difference in survival for those who received MMS as compared with WLE, suggesting MMS is an effective treatment option; further research may help provide insight as to whether MMS may offer a greater chance of tumor clearance and reduce rates of recurrence." @default.
- W4366172702 created "2023-04-19" @default.
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- W4366172702 date "2023-05-01" @default.
- W4366172702 modified "2023-09-28" @default.
- W4366172702 title "567 Mohs micrographic surgery vs. wide local excision for cutaneous sebaceous adenocarcinoma: An analysis of nationwide trends" @default.
- W4366172702 doi "https://doi.org/10.1016/j.jid.2023.03.573" @default.
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