Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366173630> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4366173630 endingPage "S89" @default.
- W4366173630 startingPage "S89" @default.
- W4366173630 abstract "Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) can be difficult to diagnose in children due to its rare occurrence, tendency to mimic common pediatric conditions, and limited scientific studies. Leveraging 30 years of longitudinal electronic health record (EHR) data within Mass General Brigham healthcare system, this study compares a pediatric cohort with DRESS to clinical manifestations in adults. Specialist-diagnosed cases were obtained using natural language processing on multiple EHR data types,and validated with manual chart review. 11 pediatric DRESS cases were identified. Median age was 15[range: 3-17,IQR:7]. Regiscar scores indicated probable(n=4,36%), possible(n=3,27%), and no DRESS(n=4,36%). Causal agents identified were Vancomycin(n=4,36%), anticonvulsants(n=3,27%), Bactrim(n=2,18%),minocycline(n=1,9%), and ibuprofen(n=1,9%). Compared to adults, erythematous maculopapular rash (n=10,91%), fever(n=11,100%), lymphadenopathy(n=4,36%),atypical lymphocytes (n=3,27%), liver injury(n=7,64%) were more prevalent while eosinophilia (n=6,55%); n=249,68%) and kidney injury(n=1,9%; n=145,39%) were less prevalent. EBV and HHV-6 were detected in 2/6 tested patients and 2/2 tested patients respectively. Three patients presented with infection prior to hospitalization with DRESS. Median length of stay was 6 days[range:0-27,IQR:15] in pediatric patients and 11 days [range:0-166,IQR 21] in adults. Zero pediatric patients compared to 4 adults suffered death from DRESS. Greater incongruence between clinical diagnosis and Regiscar score existed in pediatric patients. More pediatric cases scored probable or possible(n=7,64%;n=198,54%) and less scored definite(n=0,0%;n=55,15%). Future studies examining systemic manifestations, treatment, reliability of Regiscar scoring, and potential alterative diagnostic scales in pediatric patients should be explored." @default.
- W4366173630 created "2023-04-19" @default.
- W4366173630 creator A5010774291 @default.
- W4366173630 creator A5033512676 @default.
- W4366173630 creator A5036327055 @default.
- W4366173630 creator A5054086396 @default.
- W4366173630 creator A5074138264 @default.
- W4366173630 date "2023-05-01" @default.
- W4366173630 modified "2023-09-26" @default.
- W4366173630 title "517 Clinical manifestations of DRESS in pediatric patients" @default.
- W4366173630 doi "https://doi.org/10.1016/j.jid.2023.03.523" @default.
- W4366173630 hasPublicationYear "2023" @default.
- W4366173630 type Work @default.
- W4366173630 citedByCount "1" @default.
- W4366173630 countsByYear W43661736302023 @default.
- W4366173630 crossrefType "journal-article" @default.
- W4366173630 hasAuthorship W4366173630A5010774291 @default.
- W4366173630 hasAuthorship W4366173630A5033512676 @default.
- W4366173630 hasAuthorship W4366173630A5036327055 @default.
- W4366173630 hasAuthorship W4366173630A5054086396 @default.
- W4366173630 hasAuthorship W4366173630A5074138264 @default.
- W4366173630 hasBestOaLocation W43661736301 @default.
- W4366173630 hasConcept C126322002 @default.
- W4366173630 hasConcept C16005928 @default.
- W4366173630 hasConcept C187212893 @default.
- W4366173630 hasConcept C195910791 @default.
- W4366173630 hasConcept C2777129736 @default.
- W4366173630 hasConcept C2778570526 @default.
- W4366173630 hasConcept C71924100 @default.
- W4366173630 hasConcept C72563966 @default.
- W4366173630 hasConceptScore W4366173630C126322002 @default.
- W4366173630 hasConceptScore W4366173630C16005928 @default.
- W4366173630 hasConceptScore W4366173630C187212893 @default.
- W4366173630 hasConceptScore W4366173630C195910791 @default.
- W4366173630 hasConceptScore W4366173630C2777129736 @default.
- W4366173630 hasConceptScore W4366173630C2778570526 @default.
- W4366173630 hasConceptScore W4366173630C71924100 @default.
- W4366173630 hasConceptScore W4366173630C72563966 @default.
- W4366173630 hasIssue "5" @default.
- W4366173630 hasLocation W43661736301 @default.
- W4366173630 hasOpenAccess W4366173630 @default.
- W4366173630 hasPrimaryLocation W43661736301 @default.
- W4366173630 hasRelatedWork W1864720187 @default.
- W4366173630 hasRelatedWork W2016310235 @default.
- W4366173630 hasRelatedWork W2053627040 @default.
- W4366173630 hasRelatedWork W2289685149 @default.
- W4366173630 hasRelatedWork W2509090404 @default.
- W4366173630 hasRelatedWork W2781558459 @default.
- W4366173630 hasRelatedWork W3005064763 @default.
- W4366173630 hasRelatedWork W3171999336 @default.
- W4366173630 hasRelatedWork W60084695 @default.
- W4366173630 hasRelatedWork W2289802844 @default.
- W4366173630 hasVolume "143" @default.
- W4366173630 isParatext "false" @default.
- W4366173630 isRetracted "false" @default.
- W4366173630 workType "article" @default.