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- W4366173640 abstract "Through a prospective comparative cohort study of patients starting isotretinoin for acne (N=25), we compared mental health outcomes for 14 transmasculine patients receiving testosterone for masculinizing gender-affirming hormone therapy (mGAHT) with 11 cisgender patients at Fenway Health between September 1, 2020 and January 1, 2022. Patient Health Questionnaire-9 (PHQ-9) and Dermatology Life Quality Index (DLQI) scores were collected monthly while on isotretinoin. Median scores were compared via two-sample Wilcoxon rank-sum (Mann-Whitney) tests. By the end of their isotretinoin course, all patients achieved acne clearance with similar reduction in DLQI scores from baseline to treatment end between cohorts (mGAHT median Δ 5.5 (interquartile range (IQR) 1-9), cisgender median Δ 5 (IQR 2-8)). DLQI scores were not significantly different between the groups at baseline (mGAHT median 9 (IQR 6-12), cisgender median 6 (IQR 5-14),P=0.41) or at end of treatment (mGAHT median 3.5 (IQR 1-4), cisgender median 1 (IQR 0-4), P=0.11). At baseline, median PHQ-9 scores were significantly higher in the mGAHT group compared to the cisgender group (P=0.04) at 6.5 (IQR 4-10) and 2 (IQR 1-4), respectively. At the end of treatment, median PHQ-9 scores decreased in the mGAHT group (4.5 (IQR 2-6)) and remained stable in the cisgender group (3 (IQR 1-4)) without significant difference between the groups (P=0.94). Only one patient from each cohort reported suicidal or self-harm ideation at baseline, which improved from baseline “several days of the week” to no days by course end. Mental health outcomes improved in transmasculine patients taking isotretinoin, and cisgender patients also had stable or improved outcomes while on isotretinoin." @default.
- W4366173640 created "2023-04-19" @default.
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- W4366173640 date "2023-05-01" @default.
- W4366173640 modified "2023-09-28" @default.
- W4366173640 title "525 Isotretinoin and mental health in gender diverse patients taking testosterone compared to cisgender patients" @default.
- W4366173640 doi "https://doi.org/10.1016/j.jid.2023.03.531" @default.
- W4366173640 hasPublicationYear "2023" @default.
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